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. 2022 Jul;260(7):2309-2319.
doi: 10.1007/s00417-022-05571-3. Epub 2022 Feb 5.

Five-year follow-up of corneal morphology and corneal refractive power changes after uneventful DMEK

Apostolos Lazaridis  1 , Bogdan Spiru  2 , Elefterios Giallouros  2 , Walter Sekundo  2 , Frank Michael Schroeder  2 , Anke Messerschmidt-Roth  2 , Konstantinos Droutsas  2   3
Affiliations

Five-year follow-up of corneal morphology and corneal refractive power changes after uneventful DMEK

Apostolos Lazaridis et al. Graefes Arch Clin Exp Ophthalmol. 2022 Jul.

Abstract

Purpose: To investigate changes of corneal thickness spatial profile (CTSP), corneal volume (CV) distribution, and total corneal refractive power (TCRP) over a course of 60 months after uneventful Descemet membrane endothelial keratoplasty (DMEK).

Methods: In our prospective, comparative study, sixty DMEK cases without intraoperative and postoperative complications and with complete 60-month follow-up were included (group 1). CTSP at corneal apex (CCT) and at 2 mm, 4 mm, 6 mm, and 8 mm rings, CV in 3 mm, 5 mm, 7 mm, and 10 mm zones, and TCRF in 2 mm, 4 mm 6 mm, and 8 mm zones were evaluated preoperatively and at 3, 6, 12, 24, and 60 months postoperatively. The 60-month results were compared to an age-matched group of uncomplicated pseudophakic eyes (group 2; n = 20).

Results: The CCT and CTSP at 2, 4, and 6 mm increased significantly at 60 months compared to 3-month outcomes (P < 0.001). Similarly, CV increased significantly in 3 mm, 5 mm, and 7 mm zones at 60 months compared to 3 months outcomes (P < 0.001). The TCRP showed in all zones a significant decrease at 3 months (P < 0.001) followed by a continuous and significant increase at 60 months (P < 0.001). The 60-month CCT and CTSP at 2 mm were similar to group 2 (P ≥ 0.094).

Conclusion: Sixty months after uneventful DMEK, CT within the central 2 mm zone and CV at 3 mm zone were similar to uncomplicated pseudophakic eyes. A continuous and statistically significant increase of TCRP was observed in all measured zones after the 3-month examination.

Keywords: Corneal thickness; DMEK; Power; Tomography; Volume.

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