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Comment
. 2022 Mar;10(3):e25-e26.
doi: 10.1016/S2213-2600(21)00582-8. Epub 2022 Feb 2.

Time-dependent bias when analysing COVID-19-associated pulmonary aspergillosis

Justin de Brabander  1 , Leonoor S Boers  2 , Robert F J Kullberg  1 , Jan W Duitman  3 , Lieuwe D J Bos  4 ; ArtDeco consortium
Affiliations
Comment

Time-dependent bias when analysing COVID-19-associated pulmonary aspergillosis

Justin de Brabander et al. Lancet Respir Med. 2022 Mar.
No abstract available

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Conflict of interest statement

We declare no competing interests.

Figures

Figure
Figure
Comparison of statistical techniques. Gangneux and colleagues assumed that state 1 (intubated, without CAPA) and state 2 (intubated, with CAPA) occur independently (A), and assume that death is the only absorbing state—ignoring that patients can be extubated and are no longer at risk for CAPA, or for CAPA-related mortality in the analysis. An illness-death model without recovery and two competing endpoints is more appropriate to model the association between CAPA and outcomes (B). In this model, a patient always starts from state and can move directly or via state to two absorbing states: state 3: (extubated) and state four (death). The graphs show the estimated probability of events not accounting for time dependence (A), and accounting for time dependence (B). Solid lines show mortality and dashed lines show extubation events. The circles indicate the number of patients developing CAPA on each day (smallest circle: one patient, largest circle: five patients). CAPA=COVID-19-associated pulmonary aspergillosis.
See this image and copyright information in PMC

Comment in

Comment on

  • Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study.
    Gangneux JP, Dannaoui E, Fekkar A, Luyt CE, Botterel F, De Prost N, Tadié JM, Reizine F, Houzé S, Timsit JF, Iriart X, Riu-Poulenc B, Sendid B, Nseir S, Persat F, Wallet F, Le Pape P, Canet E, Novara A, Manai M, Cateau E, Thille AW, Brun S, Cohen Y, Alanio A, Mégarbane B, Cornet M, Terzi N, Lamhaut L, Sabourin E, Desoubeaux G, Ehrmann S, Hennequin C, Voiriot G, Nevez G, Aubron C, Letscher-Bru V, Meziani F, Blaize M, Mayaux J, Monsel A, Boquel F, Robert-Gangneux F, Le Tulzo Y, Seguin P, Guegan H, Autier B, Lesouhaitier M, Pelletier R, Belaz S, Bonnal C, Berry A, Leroy J, François N, Richard JC, Paulus S, Argaud L, Dupont D, Menotti J, Morio F, Soulié M, Schwebel C, Garnaud C, Guitard J, Le Gal S, Quinio D, Morcet J, Laviolle B, Zahar JR, Bougnoux ME. Gangneux JP, et al. Lancet Respir Med. 2022 Feb;10(2):180-190. doi: 10.1016/S2213-2600(21)00442-2. Epub 2021 Nov 26. Lancet Respir Med. 2022. PMID: 34843666 Free PMC article.

References

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