Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct;122(10):1851-1863.
doi: 10.1016/j.jand.2022.01.014. Epub 2022 Feb 2.

Adverse Effects Associated with Multiple Categories of Dietary Supplements: The Military Dietary Supplement Use Study

Joseph J Knapik  1 , Daniel W Trone  2 , Ryan A Steelman  3 , Emily K Farina  4 , Harris R Lieberman  4
Affiliations
Free article

Adverse Effects Associated with Multiple Categories of Dietary Supplements: The Military Dietary Supplement Use Study

Joseph J Knapik et al. J Acad Nutr Diet. 2022 Oct.
Free article

Abstract

Background: About 50% of Americans and 70% of US military service members (SMs) regularly use dietary supplements (DSs) and some are associated with adverse effects (AEs). SMs are more likely to use unsafe DSs than civilians.

Objective: The aim of this investigation was to examine the prevalence of, and factors associated with, AEs.

Design: Cross-sectional.

Participants: A stratified random sample of 200,000 US SMs from the Air Force, Army, Marine Corps, and Navy were obtained from military workforce records. Eighteen percent (n = 26,681) of successfully contacted SMs (n = 146,365) volunteered to participate between December 2018 and August 2019. Participants completed a detailed online questionnaire on demographic characteristics, lifestyle factors, and AEs associated with DS use.

Main outcome measure: Prevalence of, and factors associated with, AEs among DS users.

Statistical analysis: Prevalence of AEs was calculated by DS categories. Linear trends, χ2 statistics, and multivariable logistic regression examined associations between AEs and demographic characteristics, lifestyle factors, and number DSs consumed.

Results: Proportion of DS users (≥ 1 time /week) reporting ≥1 AE was 18% overall, 20% for combination products (ie, weight loss, muscle building, and before/after workout supplements), 8% for purported prohormones, 6% for protein/amino acid products, 6% for multivitamin/multiminerals, 6% for individual vitamins/minerals, 4% for herbal products, and 2% for joint health products. Combination products are very popular in military personnel with nearly half of SMs regularly taking them. In multivariable analysis, reporting AEs were independently associated with female gender, younger age, higher body mass index, smoking, higher alcohol intake, service in the Army, Navy, or Marine Corps (compared with Air Force), and consumption of a greater number of DSs.

Conclusions: A large proportion of SMs report experiencing AEs, especially users of combination products and purported prohormone supplements. This study presents contemporary data collected from a very large at-risk population on potentially hazardous categories of DSs.

Keywords: Combination products; Mineral; Multivitamin/multimineral; Prohormone; Vitamin.

PubMed Disclaimer

Publication types