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. 1978 Feb;31(1):81-5.
doi: 10.7883/yoken1952.31.81.

Enzyme-linked immunosorbent assay for detection of Clostridium botulinum toxin type A

S Notermans, J Dufrenne, M Schothorst

Enzyme-linked immunosorbent assay for detection of Clostridium botulinum toxin type A

S Notermans et al. Jpn J Med Sci Biol. 1978 Feb.

Abstract

The enzyme linked immunosorbent assay using the so-called "double-sandwich technique" has been applied to determine botulinum toxin type A. By this assay, 50-100 mouse ip LD50 of toxin type A can be detected. No cross-reaction occurs with botulinum toxins of other types tested. In all probability this is due to the high specificity of the antiserum prepared against the toxic component of type A toxin.

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