Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2022 Feb 6:28:e934282.
doi: 10.12659/MSM.934282.

Cognitive Dysfunction and Health-Related Quality of Life in Patients with End-Stage Renal Disease Undergoing Hemodialysis in Comparison with Patients Undergoing Peritoneal Dialysis: A Cross-Sectional Study

Bin Zeng  1 , Qiaoling Wang  1 , Shengkai Wu  1 , Sefen Lin  1 , Yanxian Li  1 , Wenying Jiang  1 , Ruifeng Guo  1 , Fenhui Zhou  1 , Kunzhe Lin  2
Affiliations
Comparative Study

Cognitive Dysfunction and Health-Related Quality of Life in Patients with End-Stage Renal Disease Undergoing Hemodialysis in Comparison with Patients Undergoing Peritoneal Dialysis: A Cross-Sectional Study

Bin Zeng et al. Med Sci Monit. .

Abstract

BACKGROUND This study compared the effects of peritoneal dialysis and hemodialysis on cognitive dysfunction and health-related quality of life (HRQOL) in end-stage renal disease (ESRD) patients and analyzed other potential influencing factors. MATERIAL AND METHODS A total of 265 patients who received dialysis at our hospital were included and divided into the hemodialysis group (n=115) and the peritoneal dialysis group (n=150). The cognitive performance was assessed by the Beijing version of the Montreal Cognitive Assessment. The Kidney Disease Quality of 36-Item Short Form Survey and a kidney disease-related quality of life assessment were used for evaluating HRQOL. Univariate and multivariate linear regression analyses were used to explore the effects of dialysis on cognitive dysfunction and HRQOL. RESULTS As compared with the hemodialysis group, the peritoneal dialysis group had lower scores on the Montreal Cognitive Assessment (ß=-8.35, 95% CI: -9.85 to -6.86), 36-Item Short Form Survey (ß=-10.20, 95% CI: -11.94 to -8.45), and kidney disease-related quality of life assessment (ß=-8.67, 95% CI: -10.10 to -7.23). After adjustment for sex, age, BMI, marital status, educational level, income level, presence of diabetes, duration of kidney disease, duration of dialysis, and dialysis frequency, the results were consistent with that of the crude model. CONCLUSIONS In the present study, patients receiving peritoneal dialysis had worse cognitive dysfunction and worse HRQOL compared to patients receiving hemodialysis, which might lead to poorer outcomes of ESRD patients. The related factors affecting cognitive dysfunction and HRQOL were also explored, which could help clinicians to determine the optimal treatment for ESRD patients.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared

Figures

Figure 1
Figure 1
Univariate analysis of MoCA (SAS v. 9.4, SAS Institute).
Figure 2
Figure 2
Univariate analysis of SF-36 (SAS v. 9.4, SAS Institute).
Figure 3
Figure 3
Univariate analysis of KDTA (SAS v. 9.4, SAS Institute).
See this image and copyright information in PMC

References

    1. Radić J, Ljutić D, Radić M, et al. The possible impact of dialysis modality on cognitive function in chronic dialysis patients. Neth J Med. 2010;68:153–57. - PubMed
    1. Nugent RA, Fathima SF, Feigl AB, Chyung D. The burden of chronic kidney disease on developing nations: A 21st century challenge in global health. Nephron Clin Pract. 2011;118:c269–77. - PubMed
    1. Kavanagh NT, Schiller B, Saxena AB, et al. Prevalence and correlates of functional dependence among maintenance dialysis patients. Hemodial Int. 2015;19:593–600. - PMC - PubMed
    1. O’Lone E, Connors M, Masson P, et al. Cognition in people with end-stage kidney disease treated with hemodialysis: A systematic review and meta-analysis. Am J Kidney Dis. 2016;67:925–35. - PubMed
    1. van Zwieten A, Wong G, Ruospo M, et al. Prevalence and patterns of cognitive impairment in adult hemodialysis patients: the COGNITIVE-HD study. Nephrol Dial Transplant. 2018;33:1197–206. - PubMed

Publication types