Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Mar;165(3):740-5.
doi: 10.1128/jb.165.3.740-745.1986.

Autoregulation by tandem promoters of the Salmonella typhimurium LT2 metJ gene

M L Urbanowski, G V Stauffer

Autoregulation by tandem promoters of the Salmonella typhimurium LT2 metJ gene

M L Urbanowski et al. J Bacteriol. 1986 Mar.

Abstract

Regulation of the Salmonella typhimurium metJ gene was examined by measuring beta-galactosidase activity in Escherichia coli strains lysogenic for a phage carrying a metJ-lacZ gene fusion. The results indicated that the metJ gene is regulated by its own gene product and by methionine supplementation to the growth medium. This autoregulatory mechanism involved two tandem promoters, pJ1 and pJ2, separated by approximately 65 base pairs. Deletion analysis permitted the assessment of the activity of promoters pJ1 and pJ2 individually. Promoter Pj1 was negatively regulated by the metJ gene product and by methionine. Although Pj2 regulation remained unclear, evidence is presented which suggests that it is not negatively regulated like pJ1.

PubMed Disclaimer

References

    1. Genetics. 1968 Apr;58(4):473-92 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6104-8 - PubMed
    1. Virology. 1972 Nov;50(2):373-80 - PubMed
    1. Science. 1977 Apr 8;196(4286):188-9 - PubMed
    1. Cell. 1977 Nov;12(3):847-54 - PubMed

Publication types

MeSH terms

LinkOut - more resources