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. 2022 Jan 28;28(4):497-499.
doi: 10.3748/wjg.v28.i4.497.

Interplay between chronic hepatitis B and atherosclerosis: Innovative perspectives and theories

Ivan Ranković  1 , Vladimir Milivojević  2 , Aleksandra Pavlović Marković  2 , Mihailo Bezmarević  3
Affiliations

Interplay between chronic hepatitis B and atherosclerosis: Innovative perspectives and theories

Ivan Ranković et al. World J Gastroenterol. .

Abstract

Elaboration of carotid atherosclerosis in the setting of hepatitis B virus (HBV) infection should emphasize the significance of extrahepatic manifestations of the infection pathogenesis. Diverse processes comprise the pathoevolution of HBV infection, rendering it a multi-systemic disease in its essence. Our work not only exemplified atherosclerosis as an often-underestimated contributor to the severity of HBV infection but has also highlighted the bidirectional relationship between the two. Therefore, it is suggested that HBV-induced inflammation is one of the root causes of atherosclerosis, which in turn has a consequent effect on the severity of the chronic infection disease state, creating a vicious cycle. Additionally, we coupled prior data with the current concepts of HBV infection to postulate intriguing perspectives and theories.

Keywords: Arterial inflammation; Carotid atherosclerosis; Hepatitis B e antigen; Hepatitis B virus infection; Perspectives and trends.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

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