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Review
. 2021 Dec;38(6):937-942.
doi: 10.5114/ada.2020.97394. Epub 2020 Jul 23.

SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review

Hanna Przepiera-Będzak  1 , Marek Brzosko  1
Affiliations
Review

SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review

Hanna Przepiera-Będzak et al. Postepy Dermatol Alergol. 2021 Dec.

Abstract

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role. SAPHO is classified along two different spectrums: pustulo-psoriatic hyperostotic spondyloarthritis and chronic recurrent multifocal osteomyelitis. The typical skin lesions are palmoplantar pustulosis and acne. The sign of arthritis is involvement of the anterior chest wall, most often the sternoclavicular joints. There are no standard treatment recommendations, but nonsteroidal anti-inflammatory drugs, sulfasalazine, methotrexate, antibiotics and biological drugs can be considered.

Keywords: acne; clinical presentation; comorbidities; hyperostosis and osteitis (SAPHO); imaging; pathogenesis; pustulosis; synovitis; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Chamot AM, Benhamou CL, Kahn MF, et al. Le syndrome acné pustulose hyperostose ostéite (SAPHO). Résultats d’une enquęte nationale. 85 observations. Rev Rhum Mal Osteoartic. 1987;54:187–96. - PubMed
    1. Kahn MF, Kahn MA. The SAPHO syndrome. Baillieres Clin Rheumatol. 1994;8:333–62. - PubMed
    1. Colina M, Govoni M, Orzincolo C, Trotta F. Clinical and radiological evolution of synovitis, acne, pulstulosis, hyperostosis and osteitis syndrome: a single center study of a cohort of 71 subjects. Arthritis Rheum. 2009;61:813–21. - PubMed
    1. Hayem G, Bouchaud-Chabot A, Benali K, et al. SAPHO syndrome: a long-term follow – up study of 120 cases. Semin Arthritis Rheum. 1999;29:159–71. - PubMed
    1. Przepiera-Będzak H, Brzosko I, Brzosko M. Skeletal changes during the course of pustulosis palmoplantaris – report of two cases. Pol Arch Med Wewn. 2002;107:59–62. - PubMed