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. 2022 Jan 21:12:799537.
doi: 10.3389/fendo.2021.799537. eCollection 2021.

Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

Weilun Meng  1 , Ronggang Peng  2 , Lei Du  3 , Yixing Zheng  1 , Diya Liu  4 , Shen Qu  5 , Yawei Xu  1 , Yi Zhang  6
Affiliations

Weight Loss After Laparoscopic Sleeve Gastrectomy Ameliorates the Cardiac Remodeling in Obese Chinese

Weilun Meng et al. Front Endocrinol (Lausanne). .

Abstract

This study aimed to investigate the impact of weight loss after laparoscopic sleeve gastrectomy (LSG) on cardiac structural and functional remodeling in obese Chinese. A total of 44 obese participants were enrolled consecutively. The physical, laboratory, electrocardiographic, and echocardiographic parameters of pre-and postoperative were recorded. The average follow-up time was 12.28 ± 5.80 months. The body mass index (BMI) of the patients with obesity was decreased from 41.6 ± 7.44 to 30.3 ± 5.73kg/m2 (P<0.001) after LSG. The systolic and diastolic blood pressure of the subjects was significantly reduced from 137.9 ± 15.7mmHg to 123.0 ± 16.0 and 83.4 ± 10.8 to 71.3 ± 11.7mmHg (P<0.001), respectively. The levels of fasting insulin and fasting blood glucose were significantly decreased (38.8 ± 32.1 to 8.43 ± 4.16 mU/L, P<0.001; 6.95 ± 2.59 to 4.64 ± 0.50mmol/L, P<0.001). Total cholesterol (TC, 4.66 ± 0.84 to 4.23 ± 0.75mmol/L, P<0.001) and triglyceride (TG, 1.92 ± 1.21 to 0.85 ± 0.30mmol/L, P<0.001) decreased significantly. Cardiovascular geometric parameters including aortic sinus diameter (ASD, 32.9 ± 2.83mm to 32.0 ± 3.10mm, P<0.05), left atrial diameter (LAD, 38.8 ± 4.03 to 36.2 ± 4.12mm, P<0.001), and interventricular septum thickness(IVS, 10.2 ± 0.93 to 9.64 ± 0.89mm, P<0.001) were significantly reduced. The ratio of weight loss (RWL) was positively correlated with the changes of LAD. The change of IVS was negatively correlated with the change of fasting blood glucose (GLU). Weight loss after LSG could effectively improve cardiac structural, but not functional, abnormality in obese Chinese.

Keywords: cardiac structural and functional remodeling; cardiovascular; echocardiography; obesity; sleeve gastrectomy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study. LSG, laparoscopic sleeve gastrectomy.
Figure 2
Figure 2
The BMI, electrocardiographic and echocardiographic parameters at baseline and follow-up. *P < 0.05; **P < 0.01. There was a significant decrease in anthropometric, electrocardiographic, and echocardiographic parameters, including BMI, HR, QTc, ASD, LAD, IVS, PWT, and LVmass.
Figure 3
Figure 3
The change of LAD and IVS in subgroups. *P < 0.01. The population was divided into low (L), middle (M), and high (H) subgroups according to the tri-sectional quantiles of weight loss ratio (RWL) or the change of glucose (ΔGLU). (A) showed the change of LAD was different among the subgroups (P <0.01). But (B) showed the change of IVS was not different in subgroups (P > 0.05).
See this image and copyright information in PMC

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