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. 2021 Dec 22:26:130.
doi: 10.4103/jrms.JRMS_788_18. eCollection 2021.

Polysomnography findings of patients with overlap syndrome according to severity of lower airway obstruction

Ramin Sami  1 , Samaneh Hashemi  2 , Shabnam Jalilolghadr  3
Affiliations

Polysomnography findings of patients with overlap syndrome according to severity of lower airway obstruction

Ramin Sami et al. J Res Med Sci. .

Abstract

Background: The concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is known as overlap syndrome (OS). The obstruction of the upper airway leads to OSA and the obstruction of the lower airway leads to COPD. The aim of this study was to compare polysomnographic findings of patients with OS according to severity of lower airway obstruction.

Materials and methods: Seventy-two patients were included in this cross-sectional study. Patients with COPD referred to a sleep clinic with suspicion of OSA were evaluated by polysomnography (PSG). PSG findings were interpreted based on the American Academy of Sleep Association criteria (2012). COPD severity was categorized into four groups based on GOLD criteria using forced expiratory volume in the first second (FEV1). PSG findings also were compared between patients regarding severity of lower airway obstruction (FEV1 ≥50% and FEV1 <50%).

Results: Sixty-eight of the patients had OS. Twenty-nine (42.6%) were male. The mean age was 62.3 ± 6.88 years. Thirty-two (54.4%) of the patients were in GOLD 2. The mean apnea/hypopnea index was 57.41 ± 36.16. Seventy-two percent of patients had severe OSA. Severe OSA was more prevalent in patients of GOLD 2 and 3 groups compared to the other groups. Among PSG findings, only N2 sleep stage was significantly longer in patients with FEV1 < 50% than in patients with FEV1 ≥50% (61.5 ± 11.2, 55.3 ± 13.4, P = 0.039).

Conclusion: Polysomnographic findings (except N2 stage) are not different in patients with OS with respect to severity of lower airway obstruction.

Keywords: Chronic obstructive pulmonary disease; overlap syndrome; polysomnography; sleep apnea.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Obstructive sleep apnea severity at different stages of GOLD
See this image and copyright information in PMC

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