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. 2022 Jan 27;14(1):209-223.
doi: 10.4254/wjh.v14.i1.209.

Prognostic factors of survival and a new scoring system for liver resection of colorectal liver metastasis

Kai-Chi Cheng  1 , Ada Sze-Man Yip  2
Affiliations

Prognostic factors of survival and a new scoring system for liver resection of colorectal liver metastasis

Kai-Chi Cheng et al. World J Hepatol. .

Abstract

Background: Hepatic resection has become the preferred treatment of choice for colorectal liver metastasis (CLM) patients.

Aim: To identify the prognostic factors and to formulate a new scoring system for management of CLM.

Methods: Clinicopathologic and long-term survival data were analyzed to identify the significant predictors of survival by univariate and multivariate analyses with the Cox model. A clinical score was constructed based on the analysis results.

Results: Three factors of worse overall survival were identified in the multivariate analysis. They were number of liver metastases ≥ 5, size of the largest liver lesion ≥ 4 cm, and the presence of nodal metastasis from the primary tumor. These three factors were chosen as criteria for a clinical risk score for overall survival. The clinical score highly correlated with median overall survival and 5-year survival (P = 0.002).

Conclusion: Priority over surgical resection should be given to the lowest score groups, and alternative oncological treatment should be considered in patients with the highest score.

Keywords: Colorectal cancer; Disease-free survival; Liver metastasis; Liver resection; Long-term outcome; Overall survival; Prognosis; Score.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Kaplan-Meier curves. A: Overall survival of patients with colorectal liver metastasis undergoing resection; B: Disease-free survival of patients with colorectal liver metastasis undergoing resection; C: Overall survival of patients with colorectal liver metastasis undergoing resection with difference risk scores.
See this image and copyright information in PMC

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