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Case Reports
. 2021 May 14;29(4):288-290.
doi: 10.4103/JMU.JMU_132_20. eCollection 2021 Oct-Dec.

Ceftriaxone-induced Acute Cholecystitis

Fernanda Marta Gomes  1 , Filipa Costeira  1 , Carolina Leite  1 , Pedro Silva  1
Affiliations
Case Reports

Ceftriaxone-induced Acute Cholecystitis

Fernanda Marta Gomes et al. J Med Ultrasound. .

Abstract

Ceftriaxone has been increasingly used in pediatric population, due to its bacteriological and pharmacokinetic features. Association between ceftriaxone and biliary sludge/pseudolithiasis formation has been documented in the literature. More rarely, biliary symptoms and cholecystitis during ceftriaxone therapy have been reported. We present a case of acute cholecystitis related to ceftriaxone administration and its management.

Keywords: Ceftriaxone; cholecystitis; cholecystolithiasis; contraindications; drug-induced.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Ultrasonography showing no significant abnormalities, including no evidence of gallbladder sludge or pseudolithiasis
Figure 2
Figure 2
Axial noncontrast-enhanced computed tomography image showing gallstones within the gallbladder (arrow), with no signs of inflammation
Figure 3
Figure 3
(a) Ultrasound image showing biliary sludge and pseudolithiasis formation (dashed arrow). (b and c) In addition, ultrasound images revealed (b) thickening of the gallbladder wall (arrowheads), (c) pericholecystic fluid (arrow) and probe tenderness, consistent with acute cholecystitis
Figure 4
Figure 4
Ultrasound revealed a residual amount of biliary sludge (arrowheads), considerably reduced when compared to previous examination
See this image and copyright information in PMC

References

    1. Ozturk A, Kaya M, Zeyrek D, Ozturk E, Kat N, Ziylan SZ. Ultrasonographic findings in ceftriaxone: Associated biliary sludge and pseudolithiasis in children. Acta Radiol. 2005;46:112–6. - PubMed
    1. Biner B, Öner N, Çeltik C, Bostancioğlu M, Tunçbilek N, Güzel A, et al. Ceftriaxone-associated biliary pseudolithiasis in children. J Clin Ultrasound. 2006;34:217–22. - PubMed
    1. Blais C, Duperval R. Biliary pseudolithiasis in a child associated with 2 days of ceftriaxone therapy. Pediatr Radiol. 1994;24:218–9. - PubMed
    1. Becker CD, Fischer RA. Acute cholecystitis caused by ceftriaxone stones in an adult. Case Rep Med. 2009;2009:132452. - PMC - PubMed
    1. Oggiano AM, Clemente MG, Cuzzolin L. Pharmacological treatment of ceftriaxone-related cholelithiasis in children: Is it worthwhile? J Pediatr Neonatal Individ Med. 2019;8:e080108.

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