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. 2021 Dec 25:10:51.
doi: 10.4103/abr.abr_30_20. eCollection 2021.

A Comparison of Beclomethasone Aqueous Spray and Aerosol Delivery System in Nasal Polyps: A Randomized Control Trial

Ahmad Rezaeian  1 , Amirabbas Kargoshaei  1 , Zahra Rastegar  1
Affiliations

A Comparison of Beclomethasone Aqueous Spray and Aerosol Delivery System in Nasal Polyps: A Randomized Control Trial

Ahmad Rezaeian et al. Adv Biomed Res. .

Abstract

Background: Considering the effect of beclomethasone on allergic rhinitis or nasal polyps, it has been attempted to find the best method of using this drug to have the maximum effect and increase the patients' satisfaction. Therefore, the aim of this study was to compare the efficacy of beclomethasone aerosol and aqueous nasal sprays in the patients with nasal polyps.

Materials and methods: This double-blind randomized clinical trial was conducted on 60 patients with nasal polyps. The patients were divided into two groups. The first group (beclomethasone dipropionate aqueous [BD-AQ] group) was treated with daily two puffs of beclomethasone aqueous nasal spray 50 μg in each nostril, and the second group (beclomethasone dipropionate aerosol [BD-A] group) was treated with two puffs of aerosol beclomethasone 50 μg in each nostril daily for 6 months. At the beginning of the study, the sino-nasal outcome test-22 (SNOT-22) and Lund-Mackay scores were recorded after the evaluation of disease status and the severity of symptoms.

Results: The results of this study demonstrated that the mean changes in Lund-Mackay and SNOT-22 scores (83 ± 6.30 and 4.25 ± 31.60, respectively) in the BD-A group were significantly higher than the BD-AQ group (2.01 ± 3.87and 9.83 ± 24.13, respectively) (P < 0.05), but there was no significant difference in the patients' satisfaction between the two groups (P > 0.05).

Conclusion: According to the results of this study, patients with nasal polyps showed a significant improvement following both the interventions, but the disease severity in the BD-A group was significantly higher than the BD-AQ group based on the mean values of Lund-Mackay score.

Keywords: Aerosols; Blood-Aqueous Barrier; beclomethasone; nasal polyps.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Consort patient flow diagram
Figure 2
Figure 2
Mean of sino-nasal outcome test-22 and Lund-Mackay score before and after intervention in both the groups. *A significance level of <0.001 from Wilcoxon test indicates a significant decrease in symptoms and severity of disease after intervention in both the groups
See this image and copyright information in PMC

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