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. 1986 Mar 1;163(3):697-712.
doi: 10.1084/jem.163.3.697.

Purification and partial characterization of the nephritis strain-associated protein from Streptococcus pyogenes, group A

K H Johnston, J B Zabriskie

Purification and partial characterization of the nephritis strain-associated protein from Streptococcus pyogenes, group A

K H Johnston et al. J Exp Med. .

Abstract

We report the isolation and purification of the nephritis strain-associated protein (NSAP) first described by Villareal et al. (8). Amino acid analysis, and determination of the first 21 amino-terminal amino acids indicated that this 46 kD protein is a streptokinase. Biochemical analysis confirmed that NSAP could act as a plasminogen activator; immunological investigations indicated that NSAP is antigenically different from streptokinase from group C streptococcus, and possibly represents a unique streptokinase. It is this uniqueness that may contribute to the role of NSAP in the pathogenesis of acute poststreptococcal glomerulonephritis.

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References

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