Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

M Beatrijs van der Hout-van der Jagt^{1

2

3}, E J T Verweij⁴, Peter Andriessen^{5

6}, Willem P de Boode⁷, Arend F Bos⁸, Frank L M Delbressine⁹, Alex J Eggink¹⁰, Jan Jaap H M Erwich¹¹, Loe M G Feijs⁹, Floris Groenendaal¹², Boris W W Kramer¹³, A Titia Lely¹⁴, Rachel F A M Loop^{2

9}, Franziska Neukamp¹⁵, Wes Onland¹⁶, Martijn A Oudijk¹⁷, Arjan B Te Pas¹⁸, Irwin K M Reiss¹⁹, Mark Schoberer¹⁵, Ralph R Scholten²⁰, Marc E A Spaanderman^{20

21}, Myrthe van der Ven^{1

3}, Marijn J Vermeulen^{19

22}, Frans N van de Vosse², S Guid Oei^{1

3}

Affiliations

¹ Department of Obstetrics and Gynecology, Máxima Medical Centre, Veldhoven, Netherlands.
² Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
³ Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
⁴ Department of Obstetrics and Gynecology, Division of Fetal Therapy, Leiden University Medical Center (LUMC), Leiden, Netherlands.
⁵ Department of Neonatology, Máxima Medical Centre, Veldhoven, Netherlands.
⁶ Department of Applied Physics, School of Medical Physics and Engineering Eindhoven, Eindhoven University of Technology, Eindhoven, Netherlands.
⁷ Division of Neonatology, Department of Perinatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children's Hospital, Nijmegen, Netherlands.
⁸ Department of Neonatology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, Netherlands.
⁹ Department of Industrial Design Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
¹⁰ Department of Obstetrics and Gynecology, Erasmus Medical Centre, Rotterdam, Netherlands.
¹¹ Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
¹² Department of Neonatology, Utrecht University Medical Center, Utrecht, Netherlands.
¹³ Department of Neonatology, Maastricht University Medical Center (MUMC), Maastricht, Netherlands.
¹⁴ Department of Obstetrics and Gynecology, Utrecht University Medical Center, Utrecht, Netherlands.
¹⁵ Institute for Applied Medical Engineering and Clinic for Neonatology, University Hospital Aachen, Aachen, Germany.
¹⁶ Department of Neonatology, Amsterdam UMC, Amsterdam, Netherlands.
¹⁷ Amsterdam Reproduction and Development Research Institute, Department of Obstetrics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
¹⁸ Department of Neonatology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
¹⁹ Department of Neonatology, Erasmus Medical Centre, Rotterdam, Netherlands.
²⁰ Department of Obstetrics and Gynecology, Radboud Medical Centre, Nijmegen, Netherlands.
²¹ Department of Obstetrics and Gynecology, Maastricht University Medical Center (MUMC), Maastricht, Netherlands.
²² Care4Neo Foundation, Rotterdam, Netherlands.

PMID: 35127593
PMCID: PMC8809135
DOI: 10.3389/fped.2021.793531

Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

M Beatrijs van der Hout-van der Jagt et al. Front Pediatr. 2022.

. 2022 Jan 19:9:793531.

doi: 10.3389/fped.2021.793531. eCollection 2021.

Authors

Affiliations

¹ Department of Obstetrics and Gynecology, Máxima Medical Centre, Veldhoven, Netherlands.
² Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
³ Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
⁴ Department of Obstetrics and Gynecology, Division of Fetal Therapy, Leiden University Medical Center (LUMC), Leiden, Netherlands.
⁵ Department of Neonatology, Máxima Medical Centre, Veldhoven, Netherlands.
⁶ Department of Applied Physics, School of Medical Physics and Engineering Eindhoven, Eindhoven University of Technology, Eindhoven, Netherlands.
⁷ Division of Neonatology, Department of Perinatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children's Hospital, Nijmegen, Netherlands.
⁸ Department of Neonatology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, Netherlands.
⁹ Department of Industrial Design Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
¹⁰ Department of Obstetrics and Gynecology, Erasmus Medical Centre, Rotterdam, Netherlands.
¹¹ Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
¹² Department of Neonatology, Utrecht University Medical Center, Utrecht, Netherlands.
¹³ Department of Neonatology, Maastricht University Medical Center (MUMC), Maastricht, Netherlands.
¹⁴ Department of Obstetrics and Gynecology, Utrecht University Medical Center, Utrecht, Netherlands.
¹⁵ Institute for Applied Medical Engineering and Clinic for Neonatology, University Hospital Aachen, Aachen, Germany.
¹⁶ Department of Neonatology, Amsterdam UMC, Amsterdam, Netherlands.
¹⁷ Amsterdam Reproduction and Development Research Institute, Department of Obstetrics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
¹⁸ Department of Neonatology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
¹⁹ Department of Neonatology, Erasmus Medical Centre, Rotterdam, Netherlands.
²⁰ Department of Obstetrics and Gynecology, Radboud Medical Centre, Nijmegen, Netherlands.
²¹ Department of Obstetrics and Gynecology, Maastricht University Medical Center (MUMC), Maastricht, Netherlands.
²² Care4Neo Foundation, Rotterdam, Netherlands.

PMID: 35127593
PMCID: PMC8809135
DOI: 10.3389/fped.2021.793531

Abstract

Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS technology should not only address technical issues, but also consider socio-ethical and legal aspects, its application area, and the corresponding design implications. This paper represents the consensus opinion of a group of healthcare professionals, designers, ethicists, researchers and patient representatives, who have expertise in tertiary obstetric and neonatal care, bio-ethics, experimental perinatal animal models for physiologic research, biomedical modeling, monitoring, and design. The aim of this paper is to provide a framework for research and development of PLS technology. These requirements are considering the possible respective user perspectives, with the aim to co-create a PLS system that facilitates physiological growth and development for extremely preterm born infants.

Keywords: AAPT; artificial placenta; design implications; perinatal life support; user perspectives; value-sensitive design.

Copyright © 2022 van der Hout-van der Jagt, Verweij, Andriessen, de Boode, Bos, Delbressine, Eggink, Erwich, Feijs, Groenendaal, Kramer, Lely, Loop, Neukamp, Onland, Oudijk, te Pas, Reiss, Schoberer, Scholten, Spaanderman, van der Ven, Vermeulen, van de Vosse and Oei.

PubMed Disclaimer

Conflict of interest statement

The work of MH, FD, LF, FN, MS, MV, SO, and FV has been funded by the European Union via the Horizon 2020: Future Emerging Topics call FET Open, grant EU863087, project PLS, https://cordis.europa.eu/project/id/863087. MH, MV, and SO are shareholders in Juno Perinatal Healthcare BV, Netherlands. AP is Chair of Scientific Advisory Board of Concord Neonatal BV, for which he receives no compensation, https://concordneonatal.com. He also consults for Fisher and Paykel Healthcare and receives compensation https://www.fphcare.com/en-gb. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

1. Strong KL, Pedersen J, Johansson EW, Cao B, Diaz T, Guthold R, et al. . Patterns and trends in causes of child and adolescent mortality 2000-2016: setting the scene for child health redesign. BMJ Glob Heal. (2021) 6:4760. 10.1136/bmjgh-2020-004760 - DOI - PMC - PubMed
1. March of Dimes, PMNCH, Save the children, WHO . Born Too Soon: The Global action report on preterm Birth. Eds Geneva: World Health Organization (2012). Available Online at: http://apps.who.int/iris/bitstream/handle/10665/44864/9789241503433_eng....
1. Armentrout D. Not Ready for Prime Time. J Perinat Neonatal Nurs. (2014) 28:144–9. 10.1097/JPN.0000000000000025 - DOI - PubMed
1. Evans K. Cardiovascular transition of the extremely premature infant and challenges to maintain hemodynamic stability. J Perinat Neonatal Nurs. (2016) 30:68–72. 10.1097/JPN.0000000000000156 - DOI - PubMed
1. Bolisetty S, Dhawan A, Abdel-Latif M, Bajuk B, Stack J, Lui K. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics. (2014) 133:55–62. 10.1542/peds.2013-0372 - DOI - PubMed

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

Affiliations

Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

Authors

Affiliations

Abstract

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources