Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 20:8:815640.
doi: 10.3389/fnut.2021.815640. eCollection 2021.

Bioactivities, Applications, Safety, and Health Benefits of Bioactive Peptides From Food and By-Products: A Review

Ahmed A Zaky  1 , Jesus Simal-Gandara  2 , Jong-Bang Eun  3 , Jae-Han Shim  4 , A M Abd El-Aty  5   6
Affiliations
Review

Bioactivities, Applications, Safety, and Health Benefits of Bioactive Peptides From Food and By-Products: A Review

Ahmed A Zaky et al. Front Nutr. .

Abstract

Bioactive peptides generated from food proteins have great potential as functional foods and nutraceuticals. Bioactive peptides possess several significant functions, such as antioxidative, anti-inflammatory, anticancer, antimicrobial, immunomodulatory, and antihypertensive effects in the living body. In recent years, numerous reports have been published describing bioactive peptides/hydrolysates produced from various food sources. Herein, we reviewed the bioactive peptides or protein hydrolysates found in the plant, animal, marine, and dairy products, as well as their by-products. This review also emphasizes the health benefits, bioactivities, and utilization of active peptides obtained from the mentioned sources. Their possible application in functional product development, feed, wound healing, pharmaceutical and cosmetic industries, and their use as food additives have all been investigated alongside considerations on their safety.

Keywords: applications; bioactive peptides; bioactivities; health benefits; safety.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Scheme for extracting bioactive peptides.
Figure 2
Figure 2
Bioactivities of bioactive peptides.
See this image and copyright information in PMC

References

    1. Wang N, Manabe Y, Sugawara T, Paul NA, Zhao J. Identification and biological activities of carotenoids from the freshwater alga Oedogonium intermedium. Food Chem. (2018) 242:247–55. 10.1016/j.foodchem.2017.09.075 - DOI - PubMed
    1. Szymanowska U, Baraniak B. Antioxidant and potentially anti-inflammatory activity of anthocyanin fractions from pomace obtained from enzymatically treated raspberries. Antioxidants. (2019) 8:299. 10.3390/antiox8080299 - DOI - PMC - PubMed
    1. Dziki D, Gawlik-Dziki U, Biernacka B. Cistus incanus L. as an innovative functional. Foods. (2019) 8:1–12. 10.3390/foods8080349 - DOI - PMC - PubMed
    1. Zaky AA, Chen Z, Liu Y, Li S, Jia Y. Preparation and assessment of bioactive extracts having antioxidant activity from rice bran protein hydrolysates. J Food Measur Character. (2019) 13:2542–8. 10.1007/s11694-019-00174-9 - DOI
    1. Zaky AA, Liu Y, Han P, Chen Z, Jia Y. Effect of pepsin–trypsin in vitro gastro-intestinal digestion on the antioxidant capacities of ultra-filtrated rice bran protein hydrolysates (molecular weight> 10 kDa; 3–10 kDa, and <3 kDa). Int J Pept Res Ther. (2020) 26:1661–7. 10.1007/s10989-019-09977-2 - DOI

LinkOut - more resources