Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Jan 26:25:101318.
doi: 10.1016/j.ajoc.2022.101318. eCollection 2022 Mar.

Macular edema in Cogan-Reese syndrome

Hugo Bouvarel  1 , Pascale Hamard  2 , Emilie Agard  1 , Jérémy Billant  1 , Hussam El Chehab  1 , Corinne Dot  1
Affiliations
Case Reports

Macular edema in Cogan-Reese syndrome

Hugo Bouvarel et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: Iridocorneo-endothelial (ICE) syndrome is known as a rare spectrum causing glaucoma, corneal and iris damages. Retinal complications are uncommon.

Observations: We report the case of a middle-aged woman suffering from a Cogan-Reese Syndrome (CRS) with refractory ocular hypertension (OHT) who presented a cystoid macular edema (CME) during follow up.

Conclusions and importance: We suspect the CME to be inflammatory linked to the pathophysiological hypotheses of the CRS. The CME was successfully treated with topical nonsteroidal anti-inflammatory drugs (NSAID). No consensus is available on its duration. A recurrence happened when treatment was stopped, its reintroduction was successful.

Keywords: Case report; Glaucoma; Iridocorneal endothelial syndrome; Macular edema.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The following authors have no financial disclosures:BH, HP, AE, ECH, DC.

Figures

Fig. 1
Fig. 1
a: slit lamp exam photo of the multiple small round pigmented irregular iris lesions. b: gonioscopic exam showing the same lesions (*) in the iridocorneal angle in the infero-temporal quadrant. c: anterior segment picture after the tube surgery, the arrow shows the tube in the supero-temporal position).
Fig. 2
Fig. 2
a: macular OCT, B-scan showing intraretinal cysts with a slight subfoveal fluid. b: fluorescein (left) and indocyanine (right) medium time showing unspecific diffuse macular fluorescein leakage with petaloid pooling, no indocyanine anomaly. c: macular OCT, B-scan presenting a normal foveal profile after 3 months of flurbiprofen treatment./
See this image and copyright information in PMC

References

    1. Cogan D.G., Reese A.B. A syndrome of iris nodules, ectopic Descemet's membrane, and unilateral glaucoma. Doc Ophthalmol Adv Ophthalmol. 1969;26:424–433. - PubMed
    1. Sherrard E.S., Frangoulis M.A., Muir M.G. On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome. Cornea. mai. 1991;10(3):233–243. - PubMed
    1. Robert A.M., Renard G., Robert L., Bourges J.-L. Le syndrome irido-cornéo-endothélial ou la perte du contrôle du cycle cellulaire de l’endothélium cornéen. Une revue. Pathol Biol. avr. 2013;61(2):75–82. - PubMed
    1. Silva L., Najafi A., Suwan Y., Teekhasaenee C., Ritch R. The iridocorneal endothelial syndrome. Surv Ophthalmol. sept. 2018;63(5):665–676. - PubMed
    1. Sacchetti M., Mantelli F., Marenco M., Macchi I., Ambrosio O., Rama P. Diagnosis and management of iridocorneal endothelial syndrome. BioMed Res Int. 2015;2015:1–9. - PMC - PubMed

Publication types

LinkOut - more resources