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Editorial
. 2022 Jan 24;7(1):64-66.
doi: 10.1016/j.jacbts.2021.11.008. eCollection 2022 Jan.

Cardioprotection Achieved Through Overexpression of Relaxin Receptors

Xiao-Jun Du  1   2
Affiliations
Editorial

Cardioprotection Achieved Through Overexpression of Relaxin Receptors

Xiao-Jun Du. JACC Basic Transl Sci. .
No abstract available

Keywords: gene therapy; ischemia-reperfusion; relaxin; relaxin family peptide receptor; serelaxin.

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Conflict of interest statement

The author has reported that he has no relationships relevant to the contents of this paper to disclose.

Figures

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Graphical abstract
See this image and copyright information in PMC

Comment on

  • doi: 10.1016/j.jacbts.2021.10.012

References

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    1. Sarwar M., Du X.J., Dschietzig T.B., Summers R.J. The actions of relaxin on human cardiovascular system. Br J Pharmacol. 2017;147:933–949. - PMC - PubMed
    1. Devarakonda T., Mauro A.G., Cain C., Das A., Salloum F.N. Cardiac gene therapy with relaxin receptor 1 overexpression protects against acute myocardial infarction. J Am Coll Cardiol Basic Trans Science. 2022;7(1):53–63. - PMC - PubMed
    1. Ponikowski P., Mitrovic V., Ruda M., et al. A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure. Eur Heart J. 2014;35:431–441. - PMC - PubMed
    1. Halls M.L. Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation. Br J Pharmacol. 2012;165:1644–1658. - PMC - PubMed

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