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. 2022 Apr;18(13):1627-1650.
doi: 10.2217/fon-2021-0565. Epub 2022 Feb 7.

Molecular methods for increasing the effectiveness of ovarian cancer treatment: a systematic review

Zuzanna Chilimoniuk  1 , Agata Rocka  1 , Martyna Stefaniak  1 , Żaklina Tomczyk  1 , Faustyna Jasielska  1 , Dominika Madras  1 , Agata Filip  2
Affiliations

Molecular methods for increasing the effectiveness of ovarian cancer treatment: a systematic review

Zuzanna Chilimoniuk et al. Future Oncol. 2022 Apr.

Abstract

Background: The aim of the current study is to analyze and summarize the latest research on improving therapy in ovarian cancer. Materials & methods: Data analysis was based on a review of publications from 2011 to 2021 in the PubMed database with use of the search terms including 'EGFR ovarian cancer', 'folate receptor inhibitors ovarian cancer', 'VEGF ovarian cancer', 'PDGF ovarian cancer' and 'CTLA-4 ovarian cancer'. Results: 6643 articles were found; 238 clinical trials and randomized control trials were analyzed; 122 studies were rejected due to inconsistency with the topic of the work. Conclusion: Extensive research on the treatment of ovarian cancer increases the chance of developing the most effective therapy suited to the individual needs of the patient.

Keywords: CTLA-4; EGFR; PARP; PD-1; PDGF; VEGF; ovarian cancer.

Plain language summary

Ovarian cancer is one of the most common cancers in women. Due to its nonspecific symptoms, it is often diagnosed late. This reduces the possibility of successful therapy. The main treatments are surgery and chemotherapy. With late detection, complete surgical removal of the tumor is not possible. The use of chemotherapy is limited by side effects and the resistance of cancer. Therefore, new and promising treatments are being sought. There are studies on the usage of hormone therapy in ovarian cancer. Unfortunately, a small number of these studies provide insufficient evidence of effectiveness. Hence, additional targeted therapies in ovarian cancer, and especially in immunotherapy, are of interest. Immunotherapy uses antibodies directed against specific receptors on cells important in the development of cancer. The results of the latest research on targeted methods, collected in this work, are promising.

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