Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Feb 7;15(2):e248167.
doi: 10.1136/bcr-2021-248167.

Rare case of littoral cell angioma recognised on CT simulation for adjuvant radiation treatment for early stage breast cancer

Alexander Yaney  1 , Daniel Jones  2 , Kyle A Perry  3 , Sachin R Jhawar  4
Affiliations
Case Reports

Rare case of littoral cell angioma recognised on CT simulation for adjuvant radiation treatment for early stage breast cancer

Alexander Yaney et al. BMJ Case Rep. .

Abstract

A 63-year-old woman with pathological anatomic/prognostic stage IA ER+/PR+/HER2- multifocal invasive mammary carcinoma with mixed ductal and lobular features of the left breast underwent lumpectomy with sentinel lymph node biopsy. During evaluation of the CT simulation for adjuvant radiation (RT) treatment planning, a liver lesion and splenomegaly were noted. A subsequent MRI abdomen revealed a large, indeterminate splenic lesion with a wide differential and a benign liver cyst. The patient ultimately underwent splenectomy, with pathology consistent with littoral cell angioma, a rare entity associated with several malignancies. At last follow-up, 7 months after completion of RT, she remained cancer free while on anastrazole and was doing well clinically.

Keywords: breast cancer; general surgery; pathology; radiotherapy.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
CT simulation showing an anterior, cystic-appearing lesion within the left hepatic lobe (arrow) measuring 13.2 × 6.5 mm and accompanying splenomegaly.
Figure 2
Figure 2
MRI abdomen reveals a large, indeterminate splenic mass 9.2 × 8.2 × 9.2 cm.
Figure 3
Figure 3
Littoral cell angioma. H&E, 5×.
Figure 4
Figure 4
Littoral cell angioma. H&E stain, CD31, CD68, CD8, CD34 and Ki-67 immunostains, final magnification 20×. CD34-positive cells represent admixed benign vessels.
See this image and copyright information in PMC

References

    1. Rai M, Gupta N. Littoral Cell Splenic Angioma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2021. http://www.ncbi.nlm.nih.gov/books/NBK553085/ - PubMed
    1. Dascalescu CM, Wendum D, Gorin NC. Littoral-Cell Angioma as a Cause of Splenomegaly [Internet], 2009. Available: https://www.nejm.org/doi/10.1056/NEJM200109063451016 - PubMed
    1. Peckova K, Michal M, Hadravsky L, et al. . Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies. Histopathology 2016;69:762–74. 10.1111/his.13026 - DOI - PubMed
    1. Matuszczak E, Reszec J, Dębek W, et al. . Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population? Folia Histochem Cytobiol 2012;50:480–5. 10.5603/FHC.2012.0067 - DOI - PubMed
    1. Kumar A, Kindell D, Desai CS. Littoral cell angioma of the spleen. J Gastrointest Surg 2021;25:2426–8. 10.1007/s11605-021-04980-9 - DOI - PubMed

Publication types

Supplementary concepts