Extracellular Vesicles as Novel Players in Kidney Disease

Charles J Blijdorp¹, Dylan Burger^{2

3}, Alicia Llorente^{4

5}, Elena S Martens-Uzunova⁶, Uta Erdbrügger⁷

Affiliations

¹ Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.
² Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
³ Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
⁴ Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
⁵ Department for Mechanical Electronics and Chemical Engineering, Oslo Metropolitan University, Oslo, Norway.
⁶ Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
⁷ Department of Medicine, Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia.

Charles J Blijdorp et al. J Am Soc Nephrol. 2022 Mar.

. 2022 Mar;33(3):467-471.

doi: 10.1681/ASN.2021091232. Epub 2022 Feb 7.

Charles J Blijdorp¹, Dylan Burger^{2

3}, Alicia Llorente^{4

5}, Elena S Martens-Uzunova⁶, Uta Erdbrügger⁷

¹ Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.
² Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
³ Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
⁴ Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
⁵ Department for Mechanical Electronics and Chemical Engineering, Oslo Metropolitan University, Oslo, Norway.
⁶ Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
⁷ Department of Medicine, Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia.

No abstract available

Keywords: Cell Signaling; biomarkers; exosomes; extracellular vesicles; regeneration.

Figures

1. Erdbrügger U, Blijdorp CJ, Bijnsdorp IV, Borràs FE, Burger D, Bussolati B, et al. : Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles 10: e12093, 2021 - PMC - PubMed
1. Burger D, Thibodeau JF, Holterman CE, Burns KD, Touyz RM, Kennedy CR: Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury. J Am Soc Nephrol 25: 1401–1407, 2014 - PMC - PubMed
1. Gilani SI, Anderson UD, Jayachandran M, Weissgerber TL, Zand L, White WM, et al. : Urinary extracellular vesicles of podocyte origin and renal injury in preeclampsia. J Am Soc Nephrol 28: 3363–3372, 2017 - PMC - PubMed
1. Musante L, Bontha SV, La Salvia S, Fernandez-Piñeros A, Lannigan J, Le TH, et al. : Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet - a neglected source for uEVs. Sci Rep 10: 3701, 2020 - PMC - PubMed
1. Pisitkun T, Shen RF, Knepper MA: Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A 101: 13368–13373, 2004 - PMC - PubMed