Belzutifan: a novel therapy for von Hippel-Lindau disease
- PMID: 35132216
- DOI: 10.1038/s41581-022-00544-5
Belzutifan: a novel therapy for von Hippel-Lindau disease
Comment on
-
Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.N Engl J Med. 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. N Engl J Med. 2021. PMID: 34818478 Free PMC article. Clinical Trial.
References
-
- Escudier, B. et al. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 30, 706–720 (2019). - DOI
-
- Jonasch, E. et al. Belzutifan for renal cell carcinoma in von Hippel–Lindau disease. N. Engl. J. Med. 385, 2036–2046 (2021). - DOI
-
- Kaelin, W. G. Jr. Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2, 673–682 (2002). - DOI
-
- Gnarra, J. R. et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet. 7, 85–90 (1994). - DOI
-
- Stebbins, C. E., Kaelin, W. G. Jr & Pavletich, N. P. Structure of the VHL–ElonginC–ElonginB complex: implications for VHL tumor suppressor function. Science 284, 455–461 (1999). - DOI
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
