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. 2022 Jan 29:2022:8340450.
doi: 10.1155/2022/8340450. eCollection 2022.

Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis

Songul Ozyurt  1 , Neslihan Ozcelik  1 , Bilge Yilmaz Kara  1 , Medeni Arpa  2 , Yavuz Metin  3 , Ozcan Erel  4 , Salim Neselioglu  4
Affiliations

Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis

Songul Ozyurt et al. Can Respir J. .

Abstract

Purpose: Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls.

Materials and methods: Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (-SH); TT: total thiol (-SH + SS); SS: disulfide (-SS); SS-SH: disulfide/native thiol index; SS-TT: disulphide/total thiol index; SH-TT: native thiol/total thiol index), and ischemia-modified albumin (IMA) levels were examined in the stable bronchiectasis group and the control group. Thiol-disulfide homeostasis was evaluated using a novel and automated assay. Findings and Result. Blood native thiol levels in patients with stable bronchiectasis were found to be significantly higher compared with healthy controls. A positive correlation between the total airway disease score and IMA levels was present. Our findings revealed that native thiol levels, which constitute a part of the antioxidant defense system, are increased in patients with stable bronchiectasis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Comparison between the native thiol levels in patients with bronchiectasis and the control group with an error bar graph.
Figure 2
Figure 2
The correlation between the IMA levels in the blood and total small airway disease scores.
See this image and copyright information in PMC

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