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Review
. 2022 Feb 1;21(2):172-176.
doi: 10.36849/JDD.6408.

The Heterogeneity of Atopic Dermatitis

R Chovatiya, J I Silverberg
Review

The Heterogeneity of Atopic Dermatitis

R Chovatiya et al. J Drugs Dermatol. .

Abstract

Background: Recent advances were made in characterizing the clinical heterogeneity of atopic dermatitis (AD).

Objective: To review the clinical domains contributing to AD heterogeneity and describe their importance in clinical practice.

Methods: We conducted a focused review of the published literature, including retrospective, observational, and prospective studies, clinical trials, and consensus guidelines.

Results: AD is associated with heterogeneous skin manifestations, symptoms, lesional severity, lesional extent, longitudinal course, burden of signs and symptoms, and comorbidities. Each of these domains characterizes a different aspect of AD and should be used to guide overall severity assessment and clinical management. Primary focus on any one specific clinical domain of AD is insufficient to describe the full burden of disease.

Conclusion: Heterogeneity should be routinely considered during AD clinical encounters. J Drugs Dermatol. 2022;21(2):172-176. doi:10.36849/JDD.6408.

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References

    1. Yew YW, Thyssen JP, Silverberg JI. A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics. J Am Acad Dermatol. Feb 2019;80(2):390–401. doi:10.1016/j.jaad.2018.09.035 - DOI - PubMed
    1. Silverberg JI, Gelfand JM, Margolis DJ, et al. Patient burden and quality of life in atopic dermatitis in US adults GI A population-based cross-sectional study. Ann Allerg Asthma Im. Sep 2018;121(3):340–347. doi:10.1016/j.anai.2018.07.006 - DOI - PubMed
    1. Simpson EL, Bieber T, Eckert L, et al. Patient burden of moderate to severe atopic dermatitis (AD): Insights from a phase 2b clinical trial of dupilumab in adults. J Am Acad Dermatol. Mar 2016;74(3):491–8. doi:10.1016/j.jaad.2015.10.043 - DOI - PubMed
    1. Silverberg JI, Gelfand JM, Margolis DJ, et al. Pain Is a Common and Burdensome Symptom of Atopic Dermatitis in United States Adults. J Aller Cl Imm-Pract. Nov-Dec 2019;7(8):2699-+. doi:10.1016/j.jaip.2019.05.055 - DOI - PubMed
    1. Vakharia PP, Chopra R, Sacotte R, et al. Burden of skin pain in atopic dermatitis. Ann Allergy Asthma Immunol. Dec 2017;119(6):548–552 e3. doi:10.1016/j.anai.2017.09.076 - DOI - PMC - PubMed