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Editorial
. 2022 Apr;66(4):358-360.
doi: 10.1165/rcmb.2021-0518ED.

Is CC Chemokine Ligand 17 (TARC) Driving Disease Progression in Chronic Obstructive Pulmonary Disease?

Jason Girkin  1   2
Affiliations
Editorial

Is CC Chemokine Ligand 17 (TARC) Driving Disease Progression in Chronic Obstructive Pulmonary Disease?

Jason Girkin. Am J Respir Cell Mol Biol. 2022 Apr.
No abstract available

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Figures

Figure 1.
Figure 1.
Proposed role of CCL17 in the pathogenesis of chronic obstructive pulmonary disease (COPD). Inhaled cigarette smoke or noxious stimuli cause the production of CCL17 by bronchial epithelial cells, resulting in the recruitment of macrophages (likely dual macrophages [M1/M2] phenotype) through ligation of CCL17 with the receptor CCR4 (expressed by macrophages). Macrophages then produce CCL2, perpetuating further macrophage recruitment and (potentially) the recruitment of lymphocytes such as natural killer (NK) cells and T-helper cell type 2 (Th2) cells (which may also respond to CCL17). The resulting inflammatory milieu then drives the tissue damage that leads to progressive decline in COPD. Created with BioRender.com.
See this image and copyright information in PMC

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References

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