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Review
. 2022 Nov;27(6):2137-2153.
doi: 10.1007/s10741-022-10218-w. Epub 2022 Feb 8.

Cardiorenal syndrome: long road between kidney and heart

Carolina Victoria Cruz Junho  1 , Mayra Trentin-Sonoda  2 , Karine Panico  1   3 , Raquel Silva Neres Dos Santos  1 , Mariana Vieira Abrahão  1 , Imara Caridad Stable Vernier  1 , Cristina Ribas Fürstenau  4 , Marcela Sorelli Carneiro-Ramos  5
Affiliations
Review

Cardiorenal syndrome: long road between kidney and heart

Carolina Victoria Cruz Junho et al. Heart Fail Rev. 2022 Nov.

Abstract

Almost 200 years ago, the first evidence described by Robert Bright (1836) showed the strong interaction between the kidneys and heart and, since then, the scientific community has dedicated itself to better understanding the mechanisms involved in the kidney-heart relationship, known in recent decades as cardiorenal syndrome (CRS). This syndrome includes a wide clinical variety that affects the kidneys and heart, in an acute or chronic manner. Moreover, it is well established in the literature that the immune system, the sympathetic nervous system, the renin-angiotensin-aldosterone, and the oxidative stress actively play a strong role in the cellular and molecular processes present in CRS. More recently, uremic molecules and epigenetic factors have been also shown to be key mediators in the development of syndrome. The present review intends to present the state of the art regarding CRS and to show the paths known, until now, in the long road between the kidneys and heart.

Keywords: Cardiorenal syndrome; Cardiovascular diseases; Immune system; Inflammation; Renal diseases.

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References

    1. Bright R (1836) Cases and observations illustrative of renal disease, accompanied with the secretion of albuminous urine. Medico-chirurgical Rev 25:23–35
    1. Hatamizadeh P, Fonarow GC, Budoff MJ et al (2013) Cardiorenal syndrome: pathophysiology and potential targets for clinical management. Nat Rev Nephrol 9:99–111. https://doi.org/10.1038/nrneph.2012.279 - DOI - PubMed
    1. Ronco C, McCullough P, Anker SD et al (2010) Cardio-renal syndromes: report from the consensus conference of the Acute Dialysis Quality Initiative. Eur Heart J 31:703–711. https://doi.org/10.1093/eurheartj/ehp507 - DOI - PubMed
    1. Savira F, Magaye R, Liew D et al (2020) Cardiorenal syndrome: multi-organ dysfunction involving the heart, kidney and vasculature. Br J Pharmacol 177:2906–2922. https://doi.org/10.1111/bph.15065 - DOI - PubMed - PMC
    1. Doi K, Noiri E (2016) Mitochondrial dysfunction in cardiorenal syndrome. Antioxidants Redox Signal 25:200–207. https://doi.org/10.1089/ars.2016.6654 - DOI

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