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Editorial
. 2022 May 1;163(5):bqac010.
doi: 10.1210/endocr/bqac010.

Septic Shock: A Disruptor of the Hypothalamic-Adrenal Axis as We Know It

Lynnette K Nieman  1
Affiliations
Editorial

Septic Shock: A Disruptor of the Hypothalamic-Adrenal Axis as We Know It

Lynnette K Nieman. Endocrinology. .
No abstract available

Keywords: MC2R; POMC; corticotropin-releasing hormone; cytokines; fasciculata; septic shock.

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References

    1. Tsigos C, Chrousos GP. Physiology of the hypothalamic-pituitary-adrenal axis in health and dysregulation in psychiatric and autoimmune disorders. Endocrinol Metab Clin North Am. 1994;23(3):451-466. - PubMed
    1. Boonen E, Vervenne H, Meersseman P, et al. Reduced cortisol metabolism during critical illness. N Engl J Med. 2013;368(16):1477-1488. - PMC - PubMed
    1. Boonen E, Meersseman P, Vervenne H, et al. Reduced nocturnal ACTH-driven cortisol secretion during critical illness. Am J Physiol Endocrinol Metab. 2014;306(8):E883-E892. - PMC - PubMed
    1. Téblick A, Vander Perre S, Pauwels L, et al. The role of pro-opiomelanocortin in the ACTH-cortisol dissociation of sepsis. Crit Care. 2021;25(1):65. - PMC - PubMed
    1. Téblick A, De Bruyn L, Van Oudenhove T, et al. Impact of hydrocortisone and of CRH infusion on the hypothalamus-pituitary-adrenocortical axis of septic male mice. Endocrinology. 2022;163(1):bqab222. - PMC - PubMed