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Case Reports
. 2022 Sep 1;61(17):2671-2675.
doi: 10.2169/internalmedicine.8473-21. Epub 2022 Feb 8.

Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion

Maho Adachi-Katayama  1   2 , Yuya Kondo  1 , Shota Okamoto  1 , Ryota Sato  1 , Satoshi Morinaka  1 , Taihei Nishiyama  1 , Mayu Terasaki  1 , Toshihiko Terasaki  1 , Hirofumi Toko  1 , Mizuki Yagishita  1 , Hiroyuki Takahashi  1 , Shinya Hagiwara  1 , Hiroto Tsuboi  1 , Takayuki Sumida  1 , Isao Matsumoto  1
Affiliations
Case Reports

Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion

Maho Adachi-Katayama et al. Intern Med. .

Abstract

Pleural effusion is a rare manifestation in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, which is characterized by the presence of osteoarticular lesions and dermatological involvement. We herein report a 71-year-old man with pleural effusion resulting from SAPHO syndrome. He was successfully treated using corticosteroids and has experienced no recurrence for one year. We should consider SAPHO syndrome when encountering cases of anterior chest pain and pleural fluid.

Keywords: SAPHO syndrome; anterior chest pain; hypoxia; pleural effusion.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure 1.
Figure 1.
Chest X-ray (A), pelvic X-ray (B), and lumbar spine X-ray (C). Chest X-ray (A) showed bilateral pleural effusion. Pelvic X-ray (B) revealed joint space narrowing, and supine X-ray (C) showed bamboo spine.
Figure 2.
Figure 2.
FDG PET/CT images: bilateral pleural fluid and pleural thickness with the uptake of FDG (A) and sternoclavicular joints with the slight uptake of FDG (B).
Figure 3.
Figure 3.
Contrast MRI of the thorax showed enlarged bilateral sternoclavicular joints.
Figure 4.
Figure 4.
Thoracoscopic pleural biopsy specimen (Hematoxylin and Eosin staining ×400).
Figure 5.
Figure 5.
Chest X-ray (A) after treatment and chest CT before and after treatment (B). Chest X-ray (A) demonstrated the improvement of the bilateral pleural effusion. Chest CT (B) also showed a reduction in the bilateral effusion and pleural thickening compared to before treatment.
See this image and copyright information in PMC

References

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