[De-escalation of adjuvant radiotherapy after transoral surgery of HPV-associated oropharyngeal cancer: results of the E3311 trial]
- PMID: 35137242
- PMCID: PMC8940873
- DOI: 10.1007/s00066-022-01907-4
[De-escalation of adjuvant radiotherapy after transoral surgery of HPV-associated oropharyngeal cancer: results of the E3311 trial]
Comment on
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Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311).J Clin Oncol. 2022 Jan 10;40(2):138-149. doi: 10.1200/JCO.21.01752. Epub 2021 Oct 26. J Clin Oncol. 2022. PMID: 34699271 Free PMC article. Clinical Trial.
References
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- Ma DJ, Price KA, Moore EJ, Patel SH, Hinni ML, Garcia JJ, et al. Phase II evaluation of aggressive dose de-escalation for adjuvant chemoradiotherapy in human Papillomavirus-associated oropharynx squamous cell carcinoma. J Clin Oncol. 2019;37:1909–1918. doi: 10.1200/JCO.19.00463. - DOI - PMC - PubMed
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- Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, et al. Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial. Lancet Oncol. 2019;20:1349–1359. doi: 10.1016/S1470-2045(19)30410-3. - DOI - PubMed
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- Palma DA, Prisman E, Berthelet E, Tran E, Hamilton SN, Wu J, et al. A randomized trial of radiotherapy vs. trans-oral surgery for treatment de-escalation in HPV-associated oropharyngeal squamous cell carcinoma (ORATOR2) Int J Radiat Oncol Biol Phys. 2021;111:1324–1325. doi: 10.1016/j.ijrobp.2021.09.013. - DOI
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