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Review
. 2022 Mar;58(3):388-391.
doi: 10.1111/jpc.15900. Epub 2022 Feb 9.

Subcutaneous nodules following vaccination

Anne C Collinson  1 , Lynette Moore  2 , Abigail Cheung  3 , Michael S Gold  3   4 , Day Way Goh  1   4
Affiliations
Review

Subcutaneous nodules following vaccination

Anne C Collinson et al. J Paediatr Child Health. 2022 Mar.

Abstract

Five patients presented to surgical clinics at our institution with subcutaneous nodules of the upper arm or thigh present for 6-18 months. Excisional or fine-needle biopsy was performed due to diagnostic uncertainty and parental concern. Histopathological examination revealed these to be cutaneous lymphoid hyperplasia in reaction to vaccine components. Nodular reactions with this histopathological pattern are well recognised within vaccine-related literature, but less commonly recognised in patients presenting to general paediatric or surgical clinics. This article reviews literature on delayed-onset nodule formation after vaccination and recommends observation and reassurance as mainstays of management of this largely benign entity.

Keywords: cutaneous lymphoid hyperplasia; nodule at injection site; paediatric soft tissue nodule; subcutaneous nodule; vaccination nodule.

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References

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