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Editorial
. 2022 Jul 1;43(25):2385-2387.
doi: 10.1093/eurheartj/ehac010.

You can only change what you measure: an argument for more detailed characterization in the Fontan circulation

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Editorial

You can only change what you measure: an argument for more detailed characterization in the Fontan circulation

Jack Rychik. Eur Heart J. .
No abstract available

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Graphical Abstract
Graphical Abstract
A framework for depicting the factors that influence outcomes in the Fontan circulation. Four domains of Fontan-associated challenges are proposed: (i) systemic fibrogenesis; (ii) lymphatic insufficiency; (iii) sarcopenia and exercise; and (iv) behaviour and mental health. Fontan circulation haemodynamics underlie all of these domains; however, additional factors probably influence these outcomes including: (i) variability in foetal organ development impacting substrate presenting for care at birth; (ii) social factors; (iii) genetic influences on stressors as either promoting complication or providing resilience; and (iv) potential injury accrued during the course of medical and surgical treatment.

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Comment on

References

    1. Rychik J, Atz AM, Celermajer DS, Deal BJ, Gatzoulis MA, Gewillig MH, et al. Evaluation and management of the child and adult with fontan circulation: a scientific statement from the American Heart Association. Circulation 2019;140:e234–e284. 10.1161/CIR.0000000000000696. - DOI - PubMed
    1. Inai K, Inuzuka R, Ono H, Nii M, Ohtsuki S, Kurita Y, et al. Predictors of long-term mortality among perioperative survivors of Fontan operation. Eur Heart J 2022;43:doi:10.1093/eurheartj/ehab826. - PubMed
    1. Goldberg DJ, Surrey LF, Glatz AC, Dodds K, O’Byrne ML, Lin HC, et al. Hepatic fibrosis is universal following Fontan operation, and severity is associated with time from surgery: a liver biopsy and hemodynamic study. J Am Heart Assoc 2017;6:e004809. - PMC - PubMed
    1. Trusty PM, Wei Z, Rychik J, Russo PA, Surrey LF, Goldberg DJ, et al. Impact of hemodynamics and fluid energetics on liver fibrosis after Fontan operation. J Thorac Cardiovasc Surg 2018;156:267–275. - PubMed
    1. Ghosh RM, Griffis HM, Glatz AC, Rome JJ, Smith CL, Gillespie MJ, et al. Prevalence and cause of early fontan complications: does the lymphatic circulation play a role? J Am Heart Assoc 2020;9:e015318. - PMC - PubMed