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Case Reports
. 2022 May;63(2):e155-e158.
doi: 10.1111/ajd.13803. Epub 2022 Feb 9.

Successful secukinumab treatment of active bullous pemphigoid and chronic severe psoriasis: a case report

Jenny Sw Yun  1 , Laura Scardamaglia  1   2 , Chin-Guan Tan  3 , Christopher J McCormack  4
Affiliations
Case Reports

Successful secukinumab treatment of active bullous pemphigoid and chronic severe psoriasis: a case report

Jenny Sw Yun et al. Australas J Dermatol. 2022 May.

Abstract

Since the concurrence of bullous pemphigoid (BP) and psoriasis was first reported in 1929, an increasing number of studies has been published to analyse their relationship in recent years. However, the pathogenesis of the concurrence is not yet well understood, and the coexistence of the two conditions imposes a difficult therapeutic challenge. This case report demonstrates the first case of secukinumab achieving a dramatic clinical improvement of both chronic psoriasis and active BP.

Keywords: bullous pemphigoid; immunobullous; interleukin-17; monoclonal antibody; psoriasis.

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References

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    1. Kamata M, Asano Y, Shida R et al. Secukinumab decreased circulating anti-BP180-NC16a autoantibodies in a patient with coexisting psoriasis vulgaris and bullous pemphigoid. J. Dermatol. 2019; 46: e216-e7.
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    1. Inamura E, Tsujiwaki M, Ujiie H et al. Bullous pemphigoid associated with psoriasis showing marked neutrophilic infiltrates. J. Dtsch. Dermatol. Ges. 2021; 19: 105-8.
    1. Phan K, Goyal S, Murrell DF. Association between bullous pemphigoid and psoriasis: Systematic review and meta-analysis of case-control studies. Australas. J. Dermatol. 2019; 60: 23-8.

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