Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward

David S Ludwig^{1

2

3}, Louis J Aronne⁴, Arne Astrup⁵, Rafael de Cabo⁶, Lewis C Cantley⁷, Mark I Friedman^{8

9}, Steven B Heymsfield¹⁰, James D Johnson^{11

12}, Janet C King¹³, Ronald M Krauss¹⁴, Daniel E Lieberman¹⁵, Gary Taubes⁹, Jeff S Volek¹⁶, Eric C Westman¹⁷, Walter C Willett³, William S Yancy¹⁷, Cara B Ebbeling^{1

2}

Affiliations

¹ From the New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, MA, USA.
² Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
³ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁴ Comprehensive Weight Control Center, Weill Cornell Medicine, New York, NY, USA.
⁵ Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
⁶ Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
⁷ Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
⁸ Monell Chemical Senses Center, Philadelphia, PA, USA.
⁹ Nutrition Science Initiative, San Diego, CA, USA.
¹⁰ Metabolism & Body Composition Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
¹¹ Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
¹² Institute for Personalized Therapeutic Nutrition, Vancouver, Canada.
¹³ Department of Nutritional Sciences & Toxicology, University of California Berkeley, Berkeley, CA, USA.
¹⁴ Departments of Pediatrics and Medicine, University of California San Francisco, San Francisco, CA, USA.
¹⁵ Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
¹⁶ Department of Human Sciences, Ohio State University, Columbus, OH, USA.
¹⁷ Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

PMID: 35139162
PMCID: PMC8990105
DOI: 10.1093/ajcn/nqab385

Comment

Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward

David S Ludwig et al. Am J Clin Nutr. 2022.

. 2022 Feb 9;115(2):595-597.

doi: 10.1093/ajcn/nqab385.

Authors

Affiliations

¹ From the New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, MA, USA.
² Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
³ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁴ Comprehensive Weight Control Center, Weill Cornell Medicine, New York, NY, USA.
⁵ Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
⁶ Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
⁷ Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
⁸ Monell Chemical Senses Center, Philadelphia, PA, USA.
⁹ Nutrition Science Initiative, San Diego, CA, USA.
¹⁰ Metabolism & Body Composition Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
¹¹ Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
¹² Institute for Personalized Therapeutic Nutrition, Vancouver, Canada.
¹³ Department of Nutritional Sciences & Toxicology, University of California Berkeley, Berkeley, CA, USA.
¹⁴ Departments of Pediatrics and Medicine, University of California San Francisco, San Francisco, CA, USA.
¹⁵ Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
¹⁶ Department of Human Sciences, Ohio State University, Columbus, OH, USA.
¹⁷ Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

PMID: 35139162
PMCID: PMC8990105
DOI: 10.1093/ajcn/nqab385

No abstract available

PubMed Disclaimer

Comment on

The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.
Ludwig DS, Aronne LJ, Astrup A, de Cabo R, Cantley LC, Friedman MI, Heymsfield SB, Johnson JD, King JC, Krauss RM, Lieberman DE, Taubes G, Volek JS, Westman EC, Willett WC, Yancy WS, Ebbeling CB. Ludwig DS, et al. Am J Clin Nutr. 2021 Dec 1;114(6):1873-1885. doi: 10.1093/ajcn/nqab270. Am J Clin Nutr. 2021. PMID: 34515299 Free PMC article.
Misleading or factually incorrect statements in the American Journal of Clinical Nutrition Perspectives article by Ludwig et al.
Drewnowski A, Leibel RL, Ravussin E, Redman LM, Schwartz MW, Seeley RJ, Zeltser LM. Drewnowski A, et al. Am J Clin Nutr. 2022 Feb 9;115(2):591-592. doi: 10.1093/ajcn/nqab384. Am J Clin Nutr. 2022. PMID: 35139163 Free PMC article. No abstract available.
The cabohydrate-insulin model of obesity.
Millward DJ. Millward DJ. Am J Clin Nutr. 2022 Feb 9;115(2):593-595. doi: 10.1093/ajcn/nqab383. Am J Clin Nutr. 2022. PMID: 35139164 No abstract available.
Physics and physiology of obesity: higher rate of energy input than output. Comment on "The carbohydrate-insulin model: a physiological perspective on the obesity pandemic".
Booth DA, Gibson EL. Booth DA, et al. Am J Clin Nutr. 2022 Feb 9;115(2):590-591. doi: 10.1093/ajcn/nqab382. Am J Clin Nutr. 2022. PMID: 35139169 No abstract available.
The refined carbohydrate-insulin model of obesity.
Devinsky O. Devinsky O. Am J Clin Nutr. 2022 Feb 9;115(2):592-593. doi: 10.1093/ajcn/nqab387. Am J Clin Nutr. 2022. PMID: 35139171 No abstract available.

References

1. Ludwig DS, Aronne LJ, Astrup A, de Cabo R, Cantley LC, Friedman MI, Heymsfield SB, Johnson JD, King JC, Krauss RMet al. . The carbohydrate-insulin model: a physiological perspective on the obesity pandemic. Am J Clin Nutr. 2021;114(6):1873–85. - PMC - PubMed
1. Schwartz MW, Seeley RJ, Zeltser LM, Drewnowski A, Ravussin E, Redman LM, Leibel RL. Obesity pathogenesis: an Endocrine Society Scientific Statement. Endocr Rev. 2017;38(4):267–96. - PMC - PubMed
1. American Association for the Advancement of Science (AAAS) . EurekAlert! Insulin regulates body fat independent of dietary carbohydrates. Science [Internet]. Available from:https://www.eurekalert.org/news-releases/919847(accessed 3 November 2021).
1. Ludwig DS. Second opinion: let's focus more on what we eat, not how much. Medpage Today. 18 October 2021 [Internet]. Available from:https://www.medpagetoday.com/opinion/second-opinions/95104.
1. Toates FM, Booth DA. Control of food intake by energy supply. Nature. 1974;251(5477):710–1. - PubMed

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Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward

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Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward

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