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Comment
. 2022 Feb 8;55(2):195-197.
doi: 10.1016/j.immuni.2022.01.010.

HCV neutralization goes elite

Mattia Bonsignori  1 , Joseph Marcotrigiano  2
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HCV neutralization goes elite

Mattia Bonsignori et al. Immunity. .
Free article

Abstract

A vaccine remains the most promising option to eradicate HCV. In this issue of Immunity, Weber et al. identified HCV elite neutralizers, isolated exceptionally potent and broad VH1-69 CD81-binding site neutralizing antibodies that used a shared mode of antigen recognition, and developed a computational approach that predicted mutations relevant to gain-of-function for this bnAb class, which can inform immunogen designs.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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