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. 1986 Jan;63(1):101-4.

The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease

P J Ciclitira, J M Nelufer, H J Ellis, D J Evans

The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease

P J Ciclitira et al. Clin Exp Immunol. 1986 Jan.

Abstract

Frozen sections of control and coeliac jejunal mucosa were examined for HLA-DR staining. In general the staining pattern in the controls and treated coeliac patients was a patchy subapical pattern on villous tips. Untreated coeliac patients gave a different pattern with staining extending to the crypt enterocytes. Gluten challenge in three treated coeliac patients induced an altered staining pattern within 2 h.

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