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Comment
. 2022 Feb;12(2):296-298.
doi: 10.1158/2159-8290.CD-21-1501.

The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs

Edna Cukierman  1
Affiliations
Comment

The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs

Edna Cukierman. Cancer Discov. 2022 Feb.

Abstract

Cancer-associated fibroblast (CAF) pro- and anti-pancreatic cancer functional dichotomy has been at the center of numerous studies. In this issue of Cancer Discovery, Helms and colleagues demonstrate that although pancreatic stellate cell-derived CAFs constitute a desmoplastic cell minority, these cells play a protumorigenic role via microenvironmental mechanomodulation.See related article by Helms et al., p. 484.

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References

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