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. 2022 Feb 9;7(1):43.
doi: 10.1038/s41392-022-00913-3.

ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants

Jianxia Ou #  1   2 , Yanan Zhang #  3   4 , Yongmei Wang #  1   4 , Zherui Zhang  3   4 , Hongping Wei  3   4 , Junping Yu  3   4 , Qi Wang  1 , Guifeng Wang  5   6 , Bo Zhang  7   8 , Chunhe Wang  9   10
Affiliations

ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants

Jianxia Ou et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
3E8 suppressed SARS-CoV-2 Omicron and Delta variants. Binding of different S1-subunits and 3E8 to hACE2 protein as measured by a ELISA and b BLI. c Bindings of different S1-subunits to HEK293/hACE2/EGFP and Vero E6 cells by flow cytometry. 3E8 blocked the binding of different S1-subunits to hACE2 by d ELISA and e HEK293/hACE2/EGFP cells by flow cytometry. f 3E8 blocked infections of HEK293/hACE2/EGFP cells by pseudo-typed coronaviruses. g 3E8 suppressed live Delta VOC infection in a prophylactic mouse model of COVID-19. RBD-targeting ACE2-Ig and isotype were used as positive and negative controls, respectively. h H&E staining of lung organ samples from different groups. ACE2-Ig- and isotype-treated mice developed serious interstitial pneumonia characterized by a large area of alveolar septal thickening (black arrow) and a large amount of inflammatory cell infiltration (red arrow) coupled with macrophage infiltration (yellow arrow). In contrast, less inflammatory cell infiltration (red arrow) was observed in the lungs of 3E8-treated mice. The scale represents 100 μm. i body weight changes. ***P < 0.001; ****P < 0.0001; ns, not significant
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