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Comment
. 2022 Feb;602(7898):580-581.
doi: 10.1038/d41586-022-00301-5.

Unwinding the mutational signatures of a DNA topoisomerase enzyme

Ammal Abbasi, Ludmil B Alexandrov
Comment

Unwinding the mutational signatures of a DNA topoisomerase enzyme

Ammal Abbasi et al. Nature. 2022 Feb.
No abstract available

Keywords: Cancer; Molecular biology.

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  • Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
    Reijns MAM, Parry DA, Williams TC, Nadeu F, Hindshaw RL, Rios Szwed DO, Nicholson MD, Carroll P, Boyle S, Royo R, Cornish AJ, Xiang H, Ridout K; Genomics England Research Consortium; Colorectal Cancer Domain UK 100,000 Genomes Project; Schuh A, Aden K, Palles C, Campo E, Stankovic T, Taylor MS, Jackson AP. Reijns MAM, et al. Nature. 2022 Feb;602(7898):623-631. doi: 10.1038/s41586-022-04403-y. Epub 2022 Feb 9. Nature. 2022. PMID: 35140396 Free PMC article.

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    1. Reijns, M. A. M. et al. Nature 602, 623–631 (2022). - DOI
    1. Ashour, M. E., Atteya, R. & El-Khamisy, S. F. Nature Rev. Cancer 15, 137–151 (2015). - PubMed - DOI
    1. Lippert, M. J. et al. Proc. Natl Acad. Sci. USA 108, 698–703 (2011). - PubMed - DOI

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