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. 2022 Jan 24:9:813764.
doi: 10.3389/fchem.2021.813764. eCollection 2021.

Elesesterpenes A-K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus

Dong Han  1 , Yan Liu  1 , Xiao-Mao Li  1 , Si-Yi Wang  1 , Yan Sun  1 , Adnan Mohammed Algradi  1 , Hai-Dan Zou  1 , Juan Pan  1 , Wei Guan  1 , Hai-Xue Kuang  1 , Bing-You Yang  1
Affiliations

Elesesterpenes A-K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus

Dong Han et al. Front Chem. .

Abstract

Elesesterpenes A-K (1-11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A-B (1-2) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and antiproliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) in vitro. It was found that some of them exhibited obvious anti-inflammatory activities and potent antiproliferative activities.

Keywords: Eleutherococcus sessiliflorus; anti-inflammatory; antiproliferative; nortriterpenoid; triterpenoid glycosides; triterpenoids.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

GRAPHICAL ABSTRACT
GRAPHICAL ABSTRACT
Structures of 1‐2 from Eleutherococcus sessiliflorus.
FIGURE 1
FIGURE 1
Structures of compounds 1‐11.
FIGURE 2
FIGURE 2
Key 1H‐1H COSY and HMBC correlations of compounds 1‐11.
FIGURE 3
FIGURE 3
Key NOESY correlations of compounds 1‐2, 6‐10.
FIGURE 4
FIGURE 4
X-ray crystallographic structure of 1.
FIGURE 5
FIGURE 5
X-ray crystallographic structure of 2.
FIGURE 6
FIGURE 6
Key NOESY correlations of compounds 3‐5, 11.
See this image and copyright information in PMC

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