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Review
. 2022 Jan 24:9:839055.
doi: 10.3389/fchem.2021.839055. eCollection 2021.

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

Ruinan Hao  1 , Zhuoyi Cui  1 , Xindan Zhang  1 , Ming Tian  2 , Liqun Zhang  1   2 , Feng Rao  3   4 , Jiajia Xue  1   2
Affiliations
Review

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

Ruinan Hao et al. Front Chem. .

Abstract

Skin wound healing often contains a series of dynamic and complex physiological healing processes. It is a great clinical challenge to effectively treat the cutaneous wound and regenerate the damaged skin. Hydrogels have shown great promise for skin wound healing through the rational design and preparation to endow with specific functionalities. In the mini review, we firstly introduce the design and construction of various types of hydrogels based on their bonding chemistry during cross-linking. Then, we summarize the recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling. In addition, we highlight the design strategies of responsive hydrogels to external physical stimuli. Ultimately, we provide perspectives on future directions and challenges of functional hydrogels for skin wound healing.

Keywords: bioactive materials; hydrogel; skin wound healing; tissue regeneration; wound dressing.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic showing the rational design and preparation of functional hydrogels for skin wound healing.
See this image and copyright information in PMC

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