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. 1986 Jan;29(1):63-7.
doi: 10.1007/BF02427283.

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

T Mandrup-Poulsen, K Bendtzen, J Nerup, C A Dinarello, M Svenson, J H Nielsen

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

T Mandrup-Poulsen et al. Diabetologia. 1986 Jan.

Abstract

Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets. These effects were dose-dependent and reproducible when using three different Interleukin-1 preparations. Highly purified human Interleukin-2, Lymphotoxin, Leucocyte Migration Inhibitory Factor and Macrophage Migration Inhibitory Factor were ineffective. These findings suggest that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.

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References

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