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. 1986 Apr;52(1):314-8.
doi: 10.1128/iai.52.1.314-318.1986.

Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys

W A Siddiqui, L Q Tam, S C Kan, K J Kramer, S E Case, K L Palmer, K M Yamaga, G S Hui

Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys

W A Siddiqui et al. Infect Immun. 1986 Apr.

Abstract

Monoclonal antibodies to the major Plasmodium falciparum merozoite surface coat and rhoptry antigens were produced. A combination of the affinity-purified polypeptides with Freund complete adjuvant which was given three times completely protected an Aotus lemurinus azure (karotype VI) monkey against homologous challenge; however, immunization with the same polypeptides with a muramyl dipeptide derivative [MDP-Lys(L18)] did not protect a second Aotus monkey, even though comparable high antibody titers were induced.

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References

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