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. 2022 Feb 10;20(1):3.
doi: 10.1186/s12948-022-00169-w.

Interleukin-4 can play a role in allergic rhinitis patient during treatment with Zataria multiflora

Nazila Ariaee #  1 , Yaser Yadegari #  1 , Mohamad Shabestari  2 , Javad Asili  3 , Maryam Panahi  4 , Jalal Ghorbani  1 , Farahzad Jabbari  5
Affiliations

Interleukin-4 can play a role in allergic rhinitis patient during treatment with Zataria multiflora

Nazila Ariaee et al. Clin Mol Allergy. .

Abstract

Background: Allergic rhinitis is a widespread disorder across the globe. The Shirazi thyme (Zataria multiflora) has been shown to have considerable antioxidant and anti-inflammatory properties. This study assessed the effect of this herbal product on alterations in inflammatory/anti-inflammatory cytokines.

Method: This study was conducted on the bank sample before and after the intervention to measure interleukin-4, interleukin-5, and interferon -γ levels with the ELISA test method in a supernatant taken from the PBMC cell culture from 30 allergic rhinitis patients.

Results: The IL-4 level had no significant difference between the two groups before the treatment. However, it had a significant increase in the case group after the treatment. The IL-5 level was significantly higher in the case group before the treatment. Nevertheless, there were no significant differences between the case and control groups after the treatment. Similarly, no significant differences were observed between the two groups considering IFN-γ before and after the treatment.

Conclusion: Consuming thyme with an increase in anti-inflammatory cytokine IL-4 and a decrease in IL-5 cytokine control inflammation and improvement in allergic rhinitis symptoms. Clinical trial details This clinical trial study was recorded at 22.5.2014 in the Iran Registry of Clinical Trials code: (IRCT2016121823235N6) https://www.irct.ir/trial/19852.

Keywords: Allergic rhinitis; Cytokines; IL-4; Shirazi thyme; Zataria multiflora.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
IL-4 level in supernatant of PBMC culture before and after the intervention with ZM syrup
Fig. 2
Fig. 2
IL-5 level in supernatant of PBMC culture before and after the intervention with ZM syrup
Fig. 3
Fig. 3
IFN-Ƴ level in supernatant of PBMC culture before and after the intervention with ZM syrup
See this image and copyright information in PMC

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