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Case Reports
. 2022 Feb 10;15(2):e247020.
doi: 10.1136/bcr-2021-247020.

Recurrent thrombosis as a clinical presentation of Whipple disease

María Terrones-Peinador  1 , Simeón Eremiev-Eremiev  2 , Carlos Pigrau-Serrallach  2 , Roser Solans-Laque  3
Affiliations
Case Reports

Recurrent thrombosis as a clinical presentation of Whipple disease

María Terrones-Peinador et al. BMJ Case Rep. .

Abstract

Whipple's disease (WD) is a rare infectious disease with a wide clinical spectrum. Associated thrombotic manifestations are not well described in WD, only related to 'stroke-like syndrome'. We present a case of a 39-year-old man with a 1-year history of self-limited episodes of fever, associated with generalised adenopathies and recurrent superficial and deep venous thrombosis events, which have resorted four times despite the anticoagulant treatment. Finally, the patient is diagnosed with WD. Following treatment the patient improved in his general condition, and no more episodes of fever neither thrombosis appeared during a follow-up of more than 3 years.

Keywords: bone and joint infections; haematology (incl blood transfusion); infection (gastroenterology).

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Total body maximum intensity projection. PET/CT showing increased uptake in lymphadenopathies of the pulmonary hilum, mediastinum and splenic hilum and multiple abdomino-pelvic normometabolic nodes. Hypermetabolic axillary, inguinal, supraclavicular and latero-cervical lymphadenopathies.
Figure 2
Figure 2
Timeline of the different consultations and hospitalisations of our patient and evolution after antibiotic treatment. DVT, deep vein thrombosis; SVT, superficial vein thrombosis; DOAC, direct oral anticoagulant; TMP-SMX, trimethoprim–sulfamethoxazole.
See this image and copyright information in PMC

References

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