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Comment
. 2022 Mar 10;59(3):2102806.
doi: 10.1183/13993003.02806-2021. Print 2022 Mar.

Acute exacerbation of idiopathic pulmonary fibrosis after SARS-CoV-2 vaccination

Tomohiro Bando  1 , Reoto Takei  1 , Yoshikazu Mutoh  2 , Hajime Sasano  1 , Yasuhiko Yamano  1 , Toshiki Yokoyama  1 , Toshiaki Matsuda  1 , Kensuke Kataoka  1 , Tomoki Kimura  1 , Yasuhiro Kondoh  3
Affiliations
Comment

Acute exacerbation of idiopathic pulmonary fibrosis after SARS-CoV-2 vaccination

Tomohiro Bando et al. Eur Respir J. .

Abstract

Although the association between acute exacerbation of interstitial lung disease and vaccination is not yet clarified, this is the first case report describing the possibility that SARS-CoV-2 vaccination may trigger acute exacerbation https://bit.ly/3tpu6Cz

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Conflict of interest statement

Conflict of interest: T. Bando, R. Takei, Y. Mutoh, H. Sasano, Y. Yamano, T. Yokoyama, T. Matsuda, K. Kataoka and T. Kimura have nothing to disclose. Y. Kondoh reports funding from Nippon Boehringer Ingelheim Co. Ltd, consulting fees from Asahi Kasei Pharma Corp., Shionogi & Co. Ltd, Boehringer Ingelheim Co. Ltd, Janssen Pharmaceutical K.K., Healios K.K. and Taiho Pharmaceutical Co. Ltd, and payment for lectures from Asahi Kasei Pharma Corp., Shionogi & Co. Ltd, Boehringer Ingelheim Co. Ltd, Actelion Pharmaceuticals Ltd, DAIICHI SANKYO Co. Ltd, Bristol Myers Squibb, AstraZeneca K.K., Eisai inc., KYORIN Pharmaceutical Co. Ltd, Mitsubishi Tanabe Pharma and Novartis Pharma K.K., outside the submitted work.

Figures

FIGURE 1
FIGURE 1
High-resolution computed tomography (HRCT) and chest radiograph findings with simple clinical course. a) 8 months prior to admission, subpleural reticulation and honeycomb structure are present, compatible with fibrotic interstitial lung disease. b) Chest images on admission. Newly developed bilateral and diffuse ground-glass opacities (GGO) and underlying subpleural honeycomb and reticulation are seen on HRCT. c) Chest images before discharge. GGO has improved. Below, the clinical course is shown. Numbers show clinical days from second vaccination. BAL: bronchoalveolar lavage; mPSL: methylprednisolone.
See this image and copyright information in PMC

Comment on

References

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