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Review
. 2022 Jan 25:12:827541.
doi: 10.3389/fpsyt.2021.827541. eCollection 2021.

Sleep Disturbances and Depression Are Co-morbid Conditions: Insights From Animal Models, Especially Non-human Primate Model

Meng Li  1 , Jieqiong Cui  1 , Bonan Xu  1 , Yuanyuan Wei  1 , Chenyang Fu  1 , Xiaoman Lv  1 , Lei Xiong  1 , Dongdong Qin  1
Affiliations
Review

Sleep Disturbances and Depression Are Co-morbid Conditions: Insights From Animal Models, Especially Non-human Primate Model

Meng Li et al. Front Psychiatry. .

Abstract

The incidence rates of depression are increasing year by year. As one of the main clinical manifestations of depression, sleep disorder is often the first complication. This complication may increase the severity of depression and lead to poor prognosis in patients. In the past decades, there have been many methods used to evaluate sleep disorders, such as polysomnography and electroencephalogram, actigraphy, and videography. A large number of rodents and non-human primate models have reproduced the symptoms of depression, which also show sleep disorders. The purpose of this review is to examine and discuss the relationship between sleep disorders and depression. To this end, we evaluated the prevalence, clinical features, phenotypic analysis, and pathophysiological brain mechanisms of depression-related sleep disturbances. We also emphasized the current situation, significance, and insights from animal models of depression, which would provide a better understanding for the pathophysiological mechanisms between sleep disturbance and depression.

Keywords: animal model; brain development; depression; non-human primate; sleep.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Noguti J, Andersen ML, Cirelli C, Ribeiro DA. Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association? Sleep Breath. (2013) 17:905–10. 10.1007/s11325-012-0797-9 - DOI - PubMed
    1. Pace-Schott EF, Hobson JA. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci. (2002) 3:591–605. 10.1038/nrn895 - DOI - PubMed
    1. Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. (2010) 11:114–26. 10.1038/nrn2762 - DOI - PubMed
    1. Jouvet M. Neurophysiology of the states of sleep. Physiol Rev. (1967) 47:117–77. 10.1152/physrev.1967.47.2.117 - DOI - PubMed
    1. Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. (2005) 437:1257–63. 10.1038/nature04284 - DOI - PubMed