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Review
. 2022 Jan 3:41:6.
doi: 10.11604/pamj.2022.41.6.28946. eCollection 2022.

Prognostic value of Epstein-Barr virus DNA load in nasopharyngeal carcinoma: a meta-analysis

Imane El Alami  1   2 , Amina Gihbid  1   3 , Hicham Charoute  1 , Wafaa Khaali  1 , Selma Mohamed Brahim  1 , Nezha Tawfiq  4 , Rachida Cadi  3 , Khalid Belghmi  2 , Mohammed El Mzibri  5 , Meriem Khyatti  1
Affiliations
Review

Prognostic value of Epstein-Barr virus DNA load in nasopharyngeal carcinoma: a meta-analysis

Imane El Alami et al. Pan Afr Med J. .

Abstract

The present meta-analysis was conducted to evaluate the prognostic value of pre and post-Epstein Barr Virus (EBV) DNA load testing and to assess the clinical benefit of using this molecular approach in the prognosis for a better nasopharyngeal carcinoma (NPC) management. Relevant studies were searched in different database until May 2020. Patient´s outcomes overall survival (OS), disease free survival (DFS), progression-free survival (PFS), distant-metastasis-free survival (DMFS), and local-regional-failure-free survival (LRFS), hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted from selected studies. The association of pre and post-EBV DNA load and survival outcomes was assessed using review manager and the pooled HRs with 95% CIs were calculated. Twenty-six eligible studies were included in this meta-analysis, with a total of 9966 patients. Pooled HRs showed that EBV DNA levels before and after treatment are significantly associated with survival outcomes, with HR (95% CI) of 2.09 [1.74, 2.51] for OS, 1.77 [1.19, 2.62] for DFS, 2.53 [2.18, 2.92] for DMFS, 1.78 [1.45, 2.19] for LRFS and 2.17 [1.91, 2.47] for PFS in pre-EBV DNA, and an HR (95%) of 4.52 [2.44, 8.36], 4.08 [2.38, 6.99], 5.59 [ 3.58, 8.71] and 8.88 [5.29, 14.90] for OS, DFS and PFS and DMFS in post-EBV DNA, respectively. High pre and post-EBV DNA levels were significantly associated with poor NPC patient´s survival outcomes; which clearly confirm the high interest to introduce viral EBV DNA load as a prognostic biomarker for NPC management.

Keywords: Epstein Barr Virus DNA load; Epstein-Barr virus; nasopharyngeal carcinoma; prognostic.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
flow diagram of study selection
Figure 2
Figure 2
A) the funnel plot of the 22 included studies that reported the association between pre-EBV DNA levels and OS; B) the funnel plot of the 15 included studies that examined post-EBV DNA associated OS
See this image and copyright information in PMC

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