A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa

doi:10.1016/j.jdcr.2021.12.013

Case Reports

. 2022 Jan 10:21:49-51.

doi: 10.1016/j.jdcr.2021.12.013. eCollection 2022 Mar.

A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa

Jennifer Yuying Chen^{1

2}, Elizabeth Keiser³, Philip LeBoit^{3

4

5}, Iwei Yeh^{3

4

5}, Maria L Wei^{1

4

5}

Affiliations

¹ Dermatology Service, San Francisco VA Health Care System, San Francisco, California.
² San Diego School of Medicine, University of California, San Francisco, California.
³ Pathology Department, University of California, San Francisco, California.
⁴ Dermatology Department, University of California, San Francisco, California.
⁵ Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

PMID: 35146101
PMCID: PMC8818802
DOI: 10.1016/j.jdcr.2021.12.013

Case Reports

A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa

Jennifer Yuying Chen et al. JAAD Case Rep. 2022.

. 2022 Jan 10:21:49-51.

doi: 10.1016/j.jdcr.2021.12.013. eCollection 2022 Mar.

Authors

Jennifer Yuying Chen^{1

2}, Elizabeth Keiser³, Philip LeBoit^{3

4

5}, Iwei Yeh^{3

4

5}, Maria L Wei^{1

4

5}

Affiliations

¹ Dermatology Service, San Francisco VA Health Care System, San Francisco, California.
² San Diego School of Medicine, University of California, San Francisco, California.
³ Pathology Department, University of California, San Francisco, California.
⁴ Dermatology Department, University of California, San Francisco, California.
⁵ Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

PMID: 35146101
PMCID: PMC8818802
DOI: 10.1016/j.jdcr.2021.12.013

No abstract available

Keywords: HS, hidradenitis suppurativa; KA, keratoacanthoma; NOTCH1 mutation; SCC, squamous cell carcinoma; hidradenitis suppurativa; immunocompromise; keratoacanthoma; pedunculated; squamous cell carcinoma.

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Conflict of interest statement

None disclosed.

Figures

**Fig 1**
Pedunculated, eroded keratoacanthoma in the axilla (A) at the time of teledermatology consultation and (B) in the clinic 2 weeks later.

**Fig 2**
Hematoxylin and eosin stain of patient’s keratoacanthoma. A, Low-power (×40) view demonstrates a lobular proliferation of keratinocytes with abundant eosinophilic cytoplasm. B, Higher-power view (×200) demonstrates the presence of only mild cytologic atypia of neoplastic keratinocytes and neutrophilic microabscesses within the tumor.

See this image and copyright information in PMC

Cited by

Comprehensive Catalog of Variants Potentially Associated with Hidradenitis Suppurativa, Including Newly Identified Variants from a Cohort of 100 Patients.
Muret K, Le Goff V, Dandine-Roulland C, Hotz C, Jean-Louis F, Boisson B, Mesrob L, Sandron F, Daian D, Olaso R, Le Floch E, Meyer V, Wolkenstein P, Casanova JL, Lévy Y, Bonnet E, Deleuze JF, Hüe S. Muret K, et al. Int J Mol Sci. 2024 Sep 26;25(19):10374. doi: 10.3390/ijms251910374. Int J Mol Sci. 2024. PMID: 39408704 Free PMC article.

References

1. Fenske N.A., Groover C.E., Lober C.W., Espinoza C.G. Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation. J Am Acad Dermatol. 1991;24(5):888–892. doi: 10.1016/0190-9622(91)70141-N. - DOI - PubMed
1. Tarnowski W.M. Multiple keratoacanthomata. Response of a case to systemic chemotherapy. Arch Dermatol. 1966;94(1):74–80. doi: 10.1001/archderm.1966.01600250080016. - DOI - PubMed
1. Lesage C., Adnot-Desanlis L., Perceau G., et al. Efficacy and tolerance of prolonged infliximab treatment of moderate-to-severe forms of hidradenitis suppurativa. Eur J Dermatol. 2012;22(5):640–644. doi: 10.1684/ejd.2012.1795. - DOI - PubMed
1. Lim Y.H., Fisher J.M., Bosenberg M.W., Choate K.A., Ko C.J. Keratoacanthoma shares driver mutations with cutaneous squamous cell carcinoma. J Invest Dermatol. 2016;136(8):1737–1741. doi: 10.1016/j.jid.2016.04.002. - DOI - PubMed
1. Melnik B.C., Plewig G. Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology. Exp Dermatol. 2013;22(3):172–177. doi: 10.1111/exd.12098. - DOI - PubMed

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[1] Fenske N.A., Groover C.E., Lober C.W., Espinoza C.G. Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation. J Am Acad Dermatol. 1991;24(5):888–892. doi: 10.1016/0190-9622(91)70141-N. - DOI - PubMed

[2] Fenske N.A., Groover C.E., Lober C.W., Espinoza C.G. Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation. J Am Acad Dermatol. 1991;24(5):888–892. doi: 10.1016/0190-9622(91)70141-N. - DOI - PubMed

[3] Tarnowski W.M. Multiple keratoacanthomata. Response of a case to systemic chemotherapy. Arch Dermatol. 1966;94(1):74–80. doi: 10.1001/archderm.1966.01600250080016. - DOI - PubMed

[4] Tarnowski W.M. Multiple keratoacanthomata. Response of a case to systemic chemotherapy. Arch Dermatol. 1966;94(1):74–80. doi: 10.1001/archderm.1966.01600250080016. - DOI - PubMed

[5] Lesage C., Adnot-Desanlis L., Perceau G., et al. Efficacy and tolerance of prolonged infliximab treatment of moderate-to-severe forms of hidradenitis suppurativa. Eur J Dermatol. 2012;22(5):640–644. doi: 10.1684/ejd.2012.1795. - DOI - PubMed

[6] Lesage C., Adnot-Desanlis L., Perceau G., et al. Efficacy and tolerance of prolonged infliximab treatment of moderate-to-severe forms of hidradenitis suppurativa. Eur J Dermatol. 2012;22(5):640–644. doi: 10.1684/ejd.2012.1795. - DOI - PubMed

[7] Lim Y.H., Fisher J.M., Bosenberg M.W., Choate K.A., Ko C.J. Keratoacanthoma shares driver mutations with cutaneous squamous cell carcinoma. J Invest Dermatol. 2016;136(8):1737–1741. doi: 10.1016/j.jid.2016.04.002. - DOI - PubMed

[8] Lim Y.H., Fisher J.M., Bosenberg M.W., Choate K.A., Ko C.J. Keratoacanthoma shares driver mutations with cutaneous squamous cell carcinoma. J Invest Dermatol. 2016;136(8):1737–1741. doi: 10.1016/j.jid.2016.04.002. - DOI - PubMed

[9] Melnik B.C., Plewig G. Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology. Exp Dermatol. 2013;22(3):172–177. doi: 10.1111/exd.12098. - DOI - PubMed

[10] Melnik B.C., Plewig G. Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology. Exp Dermatol. 2013;22(3):172–177. doi: 10.1111/exd.12098. - DOI - PubMed

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A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa

Affiliations

A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa

Authors

Affiliations

Conflict of interest statement

Figures

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References

Publication types

LinkOut - more resources

Full Text Sources

Research Materials