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Case Reports
. 2022 Jan 10:21:49-51.
doi: 10.1016/j.jdcr.2021.12.013. eCollection 2022 Mar.

A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa

Jennifer Yuying Chen  1   2 , Elizabeth Keiser  3 , Philip LeBoit  3   4   5 , Iwei Yeh  3   4   5 , Maria L Wei  1   4   5
Affiliations
Case Reports

A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa

Jennifer Yuying Chen et al. JAAD Case Rep. .
No abstract available

Keywords: HS, hidradenitis suppurativa; KA, keratoacanthoma; NOTCH1 mutation; SCC, squamous cell carcinoma; hidradenitis suppurativa; immunocompromise; keratoacanthoma; pedunculated; squamous cell carcinoma.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Pedunculated, eroded keratoacanthoma in the axilla (A) at the time of teledermatology consultation and (B) in the clinic 2 weeks later.
Fig 2
Fig 2
Hematoxylin and eosin stain of patient’s keratoacanthoma. A, Low-power (×40) view demonstrates a lobular proliferation of keratinocytes with abundant eosinophilic cytoplasm. B, Higher-power view (×200) demonstrates the presence of only mild cytologic atypia of neoplastic keratinocytes and neutrophilic microabscesses within the tumor.
See this image and copyright information in PMC

References

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    1. Tarnowski W.M. Multiple keratoacanthomata. Response of a case to systemic chemotherapy. Arch Dermatol. 1966;94(1):74–80. doi: 10.1001/archderm.1966.01600250080016. - DOI - PubMed
    1. Lesage C., Adnot-Desanlis L., Perceau G., et al. Efficacy and tolerance of prolonged infliximab treatment of moderate-to-severe forms of hidradenitis suppurativa. Eur J Dermatol. 2012;22(5):640–644. doi: 10.1684/ejd.2012.1795. - DOI - PubMed
    1. Lim Y.H., Fisher J.M., Bosenberg M.W., Choate K.A., Ko C.J. Keratoacanthoma shares driver mutations with cutaneous squamous cell carcinoma. J Invest Dermatol. 2016;136(8):1737–1741. doi: 10.1016/j.jid.2016.04.002. - DOI - PubMed
    1. Melnik B.C., Plewig G. Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology. Exp Dermatol. 2013;22(3):172–177. doi: 10.1111/exd.12098. - DOI - PubMed

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