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. 2022 Oct;37(10):2427-2436.
doi: 10.1007/s00467-022-05467-8. Epub 2022 Feb 10.

Impact of nephrology care trajectories pre-CKD stage 5 on initiation of kidney replacement therapy in children

Cyrielle Parmentier  1   2 , Mathilde Lassalle  3 , Etienne Berard  4 , Jérôme Harambat  5 , Cécile Couchoud  3 , Julien Hogan  6 ; REIN Registry
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Impact of nephrology care trajectories pre-CKD stage 5 on initiation of kidney replacement therapy in children

Cyrielle Parmentier et al. Pediatr Nephrol. 2022 Oct.

Abstract

Background: To improve pre-emptive kidney transplantation (PKT) in children and limit starting dialysis in an emergency, we aimed to describe nephrology care trajectories pre-CKD stage 5.

Methods: We included all children in France who, between 2010 and 2016, started kidney replacement therapy (KRT): standard dialysis (reference group) and emergency dialysis or PKT. We identified four pre-CKD stage 5 nephrology care trajectories before KRT that were extracted from the national exhaustive medical-administrative database and used logistic regression to explore associations between patient characteristics, care trajectories, and KRT initiation.

Results: Six hundred forty-three pediatric patients started KRT in France; 406 started dialysis and 30.5% emergency dialysis. The "optimal" care trajectory encompassed 179 patients, 82.7% with at least 18 months nephrology follow-up. Conversely, the "no care" trajectory encompassed 118 patients with no nephrology follow-up before KRT. The "severe" trajectory encompassed 128 patients; 93% hospitalized more than once a year and 18% in an intensive care unit. Finally, the "irregular" trajectory encompassed 127 patients, 77% and 46% with irregular laboratory monitoring and CKD drug delivery, respectively. With the "optimal" trajectory as the reference, probability of emergency dialysis was higher with the "irregular" and "no care" trajectories (odds ratio 3.02 [95% confidence interval 1.18-7.66] and 26.5 [10.8-64.8], respectively), and PKT was reduced with the "severe" trajectory (0.43 [0.23-0.82]).

Conclusion: We identified a group of patients with irregular follow-up who may benefit the most from interventions aiming at improving adherence to treatment and earlier diagnosis of their CKD to improve access to PKT. A higher resolution version of the Graphical abstract is available as Supplementary information.

Keywords: Administrative database; Care trajectories; Emergency dialysis start; Pediatric kidney transplantation; Stage 5 chronic kidney disease.

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